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Title: Increased activity of digoxin-like substance in low-renin hypertension in acromegaly

Abstract

Arterial hypertension is common in acromegaly, but the pathogenesis of this complication remains unknown. To determine the role of an endogenous Na,K pump inhibitor/digoxin-like substance (DLS) in the pathogenesis of hypertension in acromegaly 76 subjects: 28 with acromegaly, 20 with essential hypertension and 28 healthy controls were studied. Serum DLS was measured with the use of radioimmunoassay and bioassay by the inhibition of digoxin-sensitive erythrocyte 86-Rb uptake. In acromegaly, the activity of DLS was significantly increased and plasma renin activity decreased in the hypertensive group, as compared with that of the normotensive group and controls. Moreover, DLS was elevated in the low-renin group of essential hypertension, as compared with that of the normal/high-renin group or controls. The activity of DLS correlated positively with mean arterial pressure and negatively with plasma renin activity, but not with growth hormone levels. In conclusion, an endogenous sodium pump inhibitor/digoxin-like substance may play a role in the pathogenesis of low-renin hypertension in acromegaly.

Authors:
; ;  [1]
  1. Medical Center for Postgraduate Education, Warsaw (Poland)
Publication Date:
OSTI Identifier:
6870291
Resource Type:
Journal Article
Journal Name:
Clinical and Experimental Hypertension, Part A: Theory and Practice; (USA)
Additional Journal Information:
Journal Volume: 12:4; Journal ID: ISSN 0730-0077
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; DIGOXIN; BIOCHEMICAL REACTION KINETICS; HYPERTENSION; PATHOGENESIS; BLOOD PRESSURE; ERYTHROCYTES; MAN; RADIOIMMUNOASSAY; RENIN; RUBIDIUM 86; SKELETAL DISEASES; STH; ALKALI METAL ISOTOPES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOHYDRATES; CARDIAC GLYCOSIDES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DIGITALIS GLYCOSIDES; DISEASES; DRUGS; ENZYMES; GLYCOSIDES; HORMONES; HYDROLASES; IMMUNOASSAY; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; MAMMALS; MATERIALS; MINUTES LIVING RADIOISOTOPES; NONSPECIFIC PEPTIDASES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDE HYDROLASES; PITUITARY HORMONES; PRIMATES; RADIOASSAY; RADIOIMMUNODETECTION; RADIOIMMUNOLOGY; RADIOISOTOPES; REACTION KINETICS; RUBIDIUM ISOTOPES; SYMPTOMS; TRACER TECHNIQUES; VASCULAR DISEASES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Soszynski, P, Slowinska-Srzednicka, J, and Zgliczynski, S. Increased activity of digoxin-like substance in low-renin hypertension in acromegaly. United States: N. p., 1990. Web. doi:10.3109/10641969009073483.
Soszynski, P, Slowinska-Srzednicka, J, & Zgliczynski, S. Increased activity of digoxin-like substance in low-renin hypertension in acromegaly. United States. https://doi.org/10.3109/10641969009073483
Soszynski, P, Slowinska-Srzednicka, J, and Zgliczynski, S. 1990. "Increased activity of digoxin-like substance in low-renin hypertension in acromegaly". United States. https://doi.org/10.3109/10641969009073483.
@article{osti_6870291,
title = {Increased activity of digoxin-like substance in low-renin hypertension in acromegaly},
author = {Soszynski, P and Slowinska-Srzednicka, J and Zgliczynski, S},
abstractNote = {Arterial hypertension is common in acromegaly, but the pathogenesis of this complication remains unknown. To determine the role of an endogenous Na,K pump inhibitor/digoxin-like substance (DLS) in the pathogenesis of hypertension in acromegaly 76 subjects: 28 with acromegaly, 20 with essential hypertension and 28 healthy controls were studied. Serum DLS was measured with the use of radioimmunoassay and bioassay by the inhibition of digoxin-sensitive erythrocyte 86-Rb uptake. In acromegaly, the activity of DLS was significantly increased and plasma renin activity decreased in the hypertensive group, as compared with that of the normotensive group and controls. Moreover, DLS was elevated in the low-renin group of essential hypertension, as compared with that of the normal/high-renin group or controls. The activity of DLS correlated positively with mean arterial pressure and negatively with plasma renin activity, but not with growth hormone levels. In conclusion, an endogenous sodium pump inhibitor/digoxin-like substance may play a role in the pathogenesis of low-renin hypertension in acromegaly.},
doi = {10.3109/10641969009073483},
url = {https://www.osti.gov/biblio/6870291}, journal = {Clinical and Experimental Hypertension, Part A: Theory and Practice; (USA)},
issn = {0730-0077},
number = ,
volume = 12:4,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}