Comparison of magnetic resonance imaging and radionuclide imaging in the evaluation of renal transplant failure

Journal Article · Fri Apr 01 00:00:00 EST 1988 · Clin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1097/00003072-198804000-00005· OSTI ID:6858941

Goldsmith, M S; Tanasescu, D E; Waxman, A D; Crues, III, J V

Magnetic resonance imaging (MRI) was compared with radionuclide scintigraphy (RNS) in 16 patients with renal transplants undergoing renal failure to determine which modality could best discriminate between rejection, acute tubular necrosis (ATN), and cyclosporin nephrotoxicity (CN). Although all rejecting transplants had reduced corticomedullary differentiation (CMD) on T1-weighted MR images, four of five cases of ATN had appearances that could not be distinguished from rejection. A normal CMD suggests nonrejection, but diminished CMD is nonspecific. Tc-99m DTPA/I-131 hippuran RNS was superior to MRI in differentiating rejection from ATN. Although ATN and CN have similar RNS patterns, this distinction can usually be made based on the clinical time course. Other potential uses of MRI in the evaluation of the renal transplants are discussed.

• Research Organization: Cedars-Sinai Medical Center, Los Angeles, CA (USA)
• OSTI ID: 6858941
• Journal Information: Clin. Nucl. Med.; (United States), Vol. 13:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
KIDNEYS
TRANSPLANTS
NMR IMAGING
COMPARATIVE EVALUATIONS
SCINTISCANNING
UROGENITAL SYSTEM DISEASES
DIAGNOSIS
DTPA
IODINE 131
ISOMERIC NUCLEI
NUCLEAR MAGNETIC RESONANCE
ORGANOMETALLIC COMPOUNDS
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TECHNETIUM 99
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
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DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
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