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Title: Retention of {sup 99m}{Tc}-bicisate in the human brain after intracarotid injection

Abstract

{sup 99m}{Tc}-bicisate (ECD) was injected as a bolus into the internal carotid artery, and cerebral uptake and retention were recorded with fast-rotating single photon emission computed tomography (SPECT) equipment in four patients suffering from temporal lobe epilepsy. Quantitative regional cerebral blood flow (rCBF) was measured tomographically with the {sup 133}Xe inhalation technique. The authors applied a three-compartment kinetic model and algorithms modified from a previous analysis of {sup 99m}{Tc} d,l-hexamethylpropyleneamine oxide (HM-PAO) kinetics. The bicisate brain uptake and retention curve was very similar to that of HM-PAO, and it can be described by a triexponential function including an initial steep component representing the vascular transmitted spike, a second less steep component representing back-diffusion from brain tissue to blood, and a third, very slow component, representing the very slow loss due to incomplete retention of the deesterified hydrophilic metabolites. Computerized curve-fitting on data from three patients gave average kinetic values for the first-passage (unilateral) extraction of E = 0.60 (range, 0.59-0.61); the overall retained fraction of the tracer supplied was R = 0.44 (0.43-0.45), and the conversion/clearance ratio was {alpha} = k{sub 3}/k{sub 2} = 2.59 (2.38-2.77). This {alpha} is higher than that for HM-PAO, and therefore bicisate uptake as amore » function of blood flow is more linear than in HM-PAO. Less correction for backdiffusion is therefore needed. From 1 to 24 h there was an average loss of hydrophilic tracer of 3.5%/h, but the late distribution images were essentially unchanged over time, pointing to practically the same rate of loss in all regions. 18 refs., 5 figs., 2 tabs.« less

Authors:
;  [1];  [2];  [3]
  1. Bispebjerg Hospital, Copenhagen (Denmark)
  2. Rigshospitalet, Copenhagen (Denmark)
  3. Hvidovre Hospital (Denmark)
Publication Date:
OSTI Identifier:
68482
Resource Type:
Journal Article
Journal Name:
Journal of Cerebral Blood Flow and Metabolism
Additional Journal Information:
Journal Volume: 14; Journal Issue: Suppl.1; Other Information: PBD: Jan 1994
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; UPTAKE; BRAIN; METABOLISM; TECHNETIUM 99

Citation Formats

Friberg, L, Lassen, N A, Andersen, A R, and Dam, M. Retention of {sup 99m}{Tc}-bicisate in the human brain after intracarotid injection. United States: N. p., 1994. Web.
Friberg, L, Lassen, N A, Andersen, A R, & Dam, M. Retention of {sup 99m}{Tc}-bicisate in the human brain after intracarotid injection. United States.
Friberg, L, Lassen, N A, Andersen, A R, and Dam, M. 1994. "Retention of {sup 99m}{Tc}-bicisate in the human brain after intracarotid injection". United States.
@article{osti_68482,
title = {Retention of {sup 99m}{Tc}-bicisate in the human brain after intracarotid injection},
author = {Friberg, L and Lassen, N A and Andersen, A R and Dam, M},
abstractNote = {{sup 99m}{Tc}-bicisate (ECD) was injected as a bolus into the internal carotid artery, and cerebral uptake and retention were recorded with fast-rotating single photon emission computed tomography (SPECT) equipment in four patients suffering from temporal lobe epilepsy. Quantitative regional cerebral blood flow (rCBF) was measured tomographically with the {sup 133}Xe inhalation technique. The authors applied a three-compartment kinetic model and algorithms modified from a previous analysis of {sup 99m}{Tc} d,l-hexamethylpropyleneamine oxide (HM-PAO) kinetics. The bicisate brain uptake and retention curve was very similar to that of HM-PAO, and it can be described by a triexponential function including an initial steep component representing the vascular transmitted spike, a second less steep component representing back-diffusion from brain tissue to blood, and a third, very slow component, representing the very slow loss due to incomplete retention of the deesterified hydrophilic metabolites. Computerized curve-fitting on data from three patients gave average kinetic values for the first-passage (unilateral) extraction of E = 0.60 (range, 0.59-0.61); the overall retained fraction of the tracer supplied was R = 0.44 (0.43-0.45), and the conversion/clearance ratio was {alpha} = k{sub 3}/k{sub 2} = 2.59 (2.38-2.77). This {alpha} is higher than that for HM-PAO, and therefore bicisate uptake as a function of blood flow is more linear than in HM-PAO. Less correction for backdiffusion is therefore needed. From 1 to 24 h there was an average loss of hydrophilic tracer of 3.5%/h, but the late distribution images were essentially unchanged over time, pointing to practically the same rate of loss in all regions. 18 refs., 5 figs., 2 tabs.},
doi = {},
url = {https://www.osti.gov/biblio/68482}, journal = {Journal of Cerebral Blood Flow and Metabolism},
number = Suppl.1,
volume = 14,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}