Exclusion of an interactive effect of combined x-irradiation and activated cyclophosphamide in tissue culture
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effect of Cyclophosphamide (CY) on the X ray survival of clonogenic tumor cells has been studied in vitro. Two activated derivatives of the drug, Peroxycyclophosphamide and Hydroperoxycyclophosphamide, were employed. Two cell lines, repair-competent human HeLa cells and the repair-deficient rat REQ line, were investigated. Neither form of CY had any effect on the X ray survival curve of either cell line, indicating that any interaction anticipated in vivo could be expected to be additive.
- Research Organization:
- Daniel Freeman Hospital, Inglewood, CA
- OSTI ID:
- 6847383
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENDOXAN
SYNERGISM
X RADIATION
HELA CELLS
IN VITRO
RATS
SURVIVAL TIME
TISSUE CULTURES
TUMOR CELLS
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
DRUGS
ELECTROMAGNETIC RADIATION
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
MAMMALS
RADIATIONS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
ENDOXAN
SYNERGISM
X RADIATION
HELA CELLS
IN VITRO
RATS
SURVIVAL TIME
TISSUE CULTURES
TUMOR CELLS
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
DRUGS
ELECTROMAGNETIC RADIATION
IMMUNOSUPPRESSIVE DRUGS
IONIZING RADIATIONS
MAMMALS
RADIATIONS
RODENTS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture