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Title: An anatomically realistic brain phantom for quantification with positron tomography

Abstract

Phantom studies are useful in assessing and maximizing the accuracy and precision of quantification of absolute activity, assessing errors associated with patient positioning, and dosimetry. Most phantoms are limited by the use of simple shapes, which do not adequately reflect real anatomy. The authors have constructed an anatomically realistic life-size brain phantom for positron tomography studies. The phantom consists of separately fillable R + L caudates, R + L putamens, R + L globus passidus and cerebellum. These structures are contained in proper anatomic orientation within a fillable cerebrum. Solid ventricles are also present. The entire clear vinyl cerebrum is placed in a human skull. The internal brain structures were fabricated from polyester resin, with dimensions, shapes and sizes of the structures obtained from digitized contours of brain slices in the U.C.S.D. computerized brain atlas. The structures were filled with known concentrations of Ga-68 in water and scanned with our NeuroECAT. The phantom was aligned in the scanner for each structure, such that the tomographic slice passed through that structure's center. After calibration of the scanner with a standard phantom for counts/pixel uCi/cc conversion, the measured activity concentrations were compared with the actual concentrations. The ratio of measured to actualmore » activity concentration (''recovery coefficient'') for the caudate was 0.33; for the putamen 0.42. For comparison, the ratio for spheres of diameters 9.5, 16,19 and 25.4 mm was 0.23, 0.54, 0.81, and 0.93. This phantom provides more realistic assessment of performance and allows calculation of correction factors.« less

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
The Johns Hopkins Medical Institutions, Baltimore, MD
OSTI Identifier:
6843417
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008892
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 61 RADIATION PROTECTION AND DOSIMETRY; CEREBELLUM; POSITRON COMPUTED TOMOGRAPHY; CEREBRUM; PHANTOMS; FABRICATION; ACCURACY; BLOOD VESSELS; CALIBRATION; DOSIMETRY; ERRORS; ORIENTATION; PATIENTS; POSITIONING; QUANTITY RATIO; SHAPE; BODY; BRAIN; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; MOCKUP; NERVOUS SYSTEM; ORGANS; STRUCTURAL MODELS; TOMOGRAPHY; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 655003 - Medical Physics- Dosimetry

Citation Formats

Wong, D F, Links, J M, Molliver, M E, Hengst, T C, Clifford, C M, Buhle, L, Bryan, M, Stumpf, M, and Wagner, Jr, H N. An anatomically realistic brain phantom for quantification with positron tomography. United States: N. p., 1984. Web.
Wong, D F, Links, J M, Molliver, M E, Hengst, T C, Clifford, C M, Buhle, L, Bryan, M, Stumpf, M, & Wagner, Jr, H N. An anatomically realistic brain phantom for quantification with positron tomography. United States.
Wong, D F, Links, J M, Molliver, M E, Hengst, T C, Clifford, C M, Buhle, L, Bryan, M, Stumpf, M, and Wagner, Jr, H N. 1984. "An anatomically realistic brain phantom for quantification with positron tomography". United States.
@article{osti_6843417,
title = {An anatomically realistic brain phantom for quantification with positron tomography},
author = {Wong, D F and Links, J M and Molliver, M E and Hengst, T C and Clifford, C M and Buhle, L and Bryan, M and Stumpf, M and Wagner, Jr, H N},
abstractNote = {Phantom studies are useful in assessing and maximizing the accuracy and precision of quantification of absolute activity, assessing errors associated with patient positioning, and dosimetry. Most phantoms are limited by the use of simple shapes, which do not adequately reflect real anatomy. The authors have constructed an anatomically realistic life-size brain phantom for positron tomography studies. The phantom consists of separately fillable R + L caudates, R + L putamens, R + L globus passidus and cerebellum. These structures are contained in proper anatomic orientation within a fillable cerebrum. Solid ventricles are also present. The entire clear vinyl cerebrum is placed in a human skull. The internal brain structures were fabricated from polyester resin, with dimensions, shapes and sizes of the structures obtained from digitized contours of brain slices in the U.C.S.D. computerized brain atlas. The structures were filled with known concentrations of Ga-68 in water and scanned with our NeuroECAT. The phantom was aligned in the scanner for each structure, such that the tomographic slice passed through that structure's center. After calibration of the scanner with a standard phantom for counts/pixel uCi/cc conversion, the measured activity concentrations were compared with the actual concentrations. The ratio of measured to actual activity concentration (''recovery coefficient'') for the caudate was 0.33; for the putamen 0.42. For comparison, the ratio for spheres of diameters 9.5, 16,19 and 25.4 mm was 0.23, 0.54, 0.81, and 0.93. This phantom provides more realistic assessment of performance and allows calculation of correction factors.},
doi = {},
url = {https://www.osti.gov/biblio/6843417}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

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