Emetic mechanism in acute radiation sickness. Technical report, 1 December 1982-30 November 1986

Technical Report · Thu Aug 20 00:00:00 EDT 1987

OSTI ID:6840221

Borison, H L

A dose-response relationship was established in normal cats for the evocation of vomiting within 24 h after whole-body exposure to /sup 60/Co radiation with doses ranging from 7.5 to 60 Gy delivered at 1.0 Gy/min. Vomiting was recorded oscillographically. Radiation-induced vomiting was elicited unabatedly at the optimal dose of 45 Gy in chronically postremectomized cats. Radioemetic susceptibility was evaluated in normal cats after each of two doses of radiation, from 7.5 to 60 Gy, given on successive days. Occurrence of radioemetic protection against the second irradiation was manifested in direct relation to the magnitude of the first exposure, and complete protection for 24 h resulted after second radiation exposure at the highest dose level. Postremectomized cats were also fully protected against the radioemetic effect of a second exposure at 45 Gy. All normal cats vomited in response to an emetic drug injection during the state of radioemetic refractoriness after the second irradiation at 45 Gy. A neural origin of emetic signal generated by first radiation exposure was examined in postrema-intact cats.

• Research Organization: Dartmouth Coll., Hanover, NH (USA). Medical School
• OSTI ID: 6840221
• Report Number(s): AD-A-194102/0/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RADIATION PROTECTION
RADIATION SYNDROME
VOMITING
CATS
DOSE-RESPONSE RELATIONSHIPS
IRRADIATION
PROGRESS REPORT
WHOLE-BODY IRRADIATION
ANIMALS
DOCUMENT TYPES
EXTERNAL IRRADIATION
MAMMALS
SYMPTOMS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals