Serum selenium assay following serum ferritin assay
Stored serum samples can be an important research resource into the etiology of cancer. These sera cannot be replaced and should therefore be used to best advantage. In previous epidemiologic studies, only single serum constituents have been assayed in individual serum samples. For example, serum ferritin has been examined in samples stored for as long as 10 years at -20C for a possible relation with general mortality (1) and cancer death (2). Ferritin is the tissue iron-storage protein and is therefore subject to denaturation. Serum selenium has also been examined in relation to cancer risk in a prospective manner by using stored frozen serum samples (3, 4). The interactions of a variety of serum factors in relation to cancer risk would be a desirable research goal, except that the amounts of serum typically available in frozen serum banks are less than 1 ml. It was the purpose of this investigation to determine if a radioimmunoassay for ferritin affected a subsequent neutron activation assay for selenium on the same 0.1 ml serum sample.
- Research Organization:
- Battelle, Pacific Northwest Labs., Richland, WA
- OSTI ID:
- 6840207
- Journal Information:
- Am. J. Epidemiol.; (United States), Vol. 124:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLOOD SERUM
ACTIVATION ANALYSIS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOIMMUNOASSAY
FERRITIN
MEASURING METHODS
NEOPLASMS
NEUTRON REACTIONS
SELENIUM
BARYON REACTIONS
CHEMICAL ANALYSIS
COMPLEXES
DISEASES
ELEMENTS
HADRON REACTIONS
IMMUNOASSAY
IMMUNOLOGY
IRON COMPLEXES
ISOTOPE APPLICATIONS
METALLOPROTEINS
NUCLEAR REACTIONS
NUCLEON REACTIONS
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
SEMIMETALS
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
560300* - Chemicals Metabolism & Toxicology