Ozone-induced changes in the pulmonary clearance of (99m)Tc-DTPA in man
Ozone is a respiratory irritant that has been shown in animals to increase the premeability of the respiratory epithelium. In the study the authors have recently reported that respiratory epithelial permeability was similarly affected in eight healthy non-smoking young men exposed to ozone (ARRD, 135 (1987) 1124-8). Permeability was evaluated by determining the pulmonary clearance of inhaled aerosolized 99mTc-DTPA with sequential posterior lung imaging by a computer-assisted gamma camera. In a randomized crossover design, 16 young men were exposed for 2 h to purified air and 0.4 ppm ozone while performing intermittent high intensity treadmill exercise; forced vital capacity (FVC) was measured before and at the end of exposures. The results demonstrate that ozone exposure increased respiratory epithelial permeability. Such an increase may be a manifestation of direct ozone-induced epithelial-cell injury, lung inflammation, or both.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6840116
- Report Number(s):
- PB-88-214705/XAB; EPA-600/D-88/113
- Country of Publication:
- United States
- Language:
- English
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Ozone exposure increases respiratory epithelial permeability in humans (journal version)
Related Subjects
54 ENVIRONMENTAL SCIENCES
DTPA
LUNG CLEARANCE
OZONE
BIOLOGICAL EFFECTS
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
TRACER TECHNIQUES
INHALATION
RESPIRATION
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DISEASES
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology
500300 - Environment
Atmospheric- Radioactive Materials Monitoring & Transport- (-1989)