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Title: Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy

Abstract

Morbidity and survival patterns were reviewed in 50 patients who underwent radical hysterectomy, pelvic lymphadenectomy, and adjuvant postoperative pelvic radiotherapy for invasive cervical cancer. Ninety percent of the patients were FIGO stage IB, and 10% were clinical stage IIA or IIB. Indications for adjuvant radiotherapy included pelvic lymph node metastasis, large volume, deep stromal penetration, lower uterine segment involvement, or capillary space involvement. Seventy-two percent of the patients had multiple high-risk factors. An average of 4700 cGy of whole-pelvis radiotherapy was administered. Ten percent of the patients suffered major gastrointestinal complications, 14% minor gastrointestinal morbidity, 12% minor genitourinary complications, one patient a lymphocyst, and one patient lymphedema. Of the five patients with major gastrointestinal morbidity, all occurred within 12 months of treatment. Three patients required intestinal bypass surgery for distal ileal obstructions and all are currently doing well and free of disease. All of the patients who developed recurrent disease had multiple, high-risk factors. The median time of recurrence was 12 months. All patients recurred within the radiated field. Actuarial survival was 90% and disease-free survival 87% at 70 months. It is our opinion that the morbidity of postoperative pelvic radiotherapy is acceptable, and benefit may be gained in suchmore » a high-risk patient population.« less

Authors:
; ; ; ; ;  [1]
  1. Univ.ersity of South Florida College of Medicine, Tampa (USA)
Publication Date:
OSTI Identifier:
6834754
Resource Type:
Journal Article
Journal Name:
Gynecologic Oncology; (USA)
Additional Journal Information:
Journal Volume: 36:3; Journal ID: ISSN 0090-8258
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; NEOPLASMS; RADIOTHERAPY; SIDE EFFECTS; UTERUS; MAN; PATIENTS; POST-IRRADIATION EXAMINATION; RADIATION INJURIES; SURGERY; SURVIVAL CURVES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; FEMALE GENITALS; INJURIES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; ORGANS; PRIMATES; RADIATION EFFECTS; RADIOLOGY; THERAPY; VERTEBRATES; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man

Citation Formats

Fiorica, J V, Roberts, W S, Greenberg, H, Hoffman, M S, LaPolla, J P, and Cavanagh, D. Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy. United States: N. p., 1990. Web. doi:10.1016/0090-8258(90)90139-C.
Fiorica, J V, Roberts, W S, Greenberg, H, Hoffman, M S, LaPolla, J P, & Cavanagh, D. Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy. United States. https://doi.org/10.1016/0090-8258(90)90139-C
Fiorica, J V, Roberts, W S, Greenberg, H, Hoffman, M S, LaPolla, J P, and Cavanagh, D. 1990. "Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy". United States. https://doi.org/10.1016/0090-8258(90)90139-C.
@article{osti_6834754,
title = {Morbidity and survival patterns in patients after radical hysterectomy and postoperative adjuvant pelvic radiotherapy},
author = {Fiorica, J V and Roberts, W S and Greenberg, H and Hoffman, M S and LaPolla, J P and Cavanagh, D},
abstractNote = {Morbidity and survival patterns were reviewed in 50 patients who underwent radical hysterectomy, pelvic lymphadenectomy, and adjuvant postoperative pelvic radiotherapy for invasive cervical cancer. Ninety percent of the patients were FIGO stage IB, and 10% were clinical stage IIA or IIB. Indications for adjuvant radiotherapy included pelvic lymph node metastasis, large volume, deep stromal penetration, lower uterine segment involvement, or capillary space involvement. Seventy-two percent of the patients had multiple high-risk factors. An average of 4700 cGy of whole-pelvis radiotherapy was administered. Ten percent of the patients suffered major gastrointestinal complications, 14% minor gastrointestinal morbidity, 12% minor genitourinary complications, one patient a lymphocyst, and one patient lymphedema. Of the five patients with major gastrointestinal morbidity, all occurred within 12 months of treatment. Three patients required intestinal bypass surgery for distal ileal obstructions and all are currently doing well and free of disease. All of the patients who developed recurrent disease had multiple, high-risk factors. The median time of recurrence was 12 months. All patients recurred within the radiated field. Actuarial survival was 90% and disease-free survival 87% at 70 months. It is our opinion that the morbidity of postoperative pelvic radiotherapy is acceptable, and benefit may be gained in such a high-risk patient population.},
doi = {10.1016/0090-8258(90)90139-C},
url = {https://www.osti.gov/biblio/6834754}, journal = {Gynecologic Oncology; (USA)},
issn = {0090-8258},
number = ,
volume = 36:3,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 1990},
month = {Thu Mar 01 00:00:00 EST 1990}
}