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Title: Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds

Abstract

The mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and other environmentally related compounds was determined using Salmonella typhimurium strain TA98 in the standard plate incorporation assay. Samples tested included binary mixtures of 4-nitro-4'-chlorobiphenyl with 6-nitro-4,2',3',4',5'-pentachlorobiphenyl, 4-nitrobenzo-p-dioxin with 4-nitro-2,3,8-trichlorodibenzo-p-dioxin, and benzo(a)pyrene with either nitropentachlorobiphenyl or nitrotrichlorodibenzo-p-dioxin. Inhibition was the primary interaction observed for the mixtures of polyhalogenated dioxins or biphenyls with the direct-acting mutagens nitrodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlorodibenzo-p-dioxin inhibited the bacterial mutagenicity of nitrodibenzo-p-dioxin by almost 50%, while pentachlorobiphenyl inhibited the mutagenicity of nitrobiphenyl by 34%. Conversely, synergism was the primary interaction observed for mixtures of halogenated aromatics with the promutagen benzo(a)pyrene. The addition of nitrotrichlorodioxin to benzo(a)pyrene enhanced the mutagenicity of the latter compound by as much as 70%, while the mutagenic potential of a mixture of benzo(a)pyrene and nitropentachlorobiphenyl was approximately 50% greater than the mutagenicity of benzo(a)pyrene alone. In summary, mixtures of nonmutagenic nitropolyhalogenated biphenyls or dibenzo-p-dioxins appear to inhibit the mutagenicity of direct-acting mutagens, while these same compounds seem to enhance the mutagenic potential of the promutagen benzo(a)pyrene.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Texas A and M Univ., College Station (USA)
OSTI Identifier:
6834585
Resource Type:
Journal Article
Journal Name:
J. Toxicol. Environ. Health; (United States)
Additional Journal Information:
Journal Volume: 24:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BENZOPYRENE; MUTAGEN SCREENING; CHLORINATED AROMATIC HYDROCARBONS; DIOXIN; NITRO COMPOUNDS; MIXTURES; MUTAGENESIS; MUTAGENS; RATS; SALMONELLA TYPHIMURIUM; SYNERGISM; TOXICITY; ANIMALS; AROMATICS; BACTERIA; CONDENSED AROMATICS; DISPERSIONS; HALOGENATED AROMATIC HYDROCARBONS; HETEROCYCLIC COMPOUNDS; HYDROCARBONS; MAMMALS; MICROORGANISMS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; RODENTS; SALMONELLA; SCREENING; VERTEBRATES; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Donnelly, K C, Brown, K W, Estiri, M, Jones, D H, and Safe, S. Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds. United States: N. p., 1988. Web. doi:10.1080/15287398809531166.
Donnelly, K C, Brown, K W, Estiri, M, Jones, D H, & Safe, S. Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds. United States. https://doi.org/10.1080/15287398809531166
Donnelly, K C, Brown, K W, Estiri, M, Jones, D H, and Safe, S. 1988. "Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds". United States. https://doi.org/10.1080/15287398809531166.
@article{osti_6834585,
title = {Mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and related compounds},
author = {Donnelly, K C and Brown, K W and Estiri, M and Jones, D H and Safe, S},
abstractNote = {The mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p-dioxins and other environmentally related compounds was determined using Salmonella typhimurium strain TA98 in the standard plate incorporation assay. Samples tested included binary mixtures of 4-nitro-4'-chlorobiphenyl with 6-nitro-4,2',3',4',5'-pentachlorobiphenyl, 4-nitrobenzo-p-dioxin with 4-nitro-2,3,8-trichlorodibenzo-p-dioxin, and benzo(a)pyrene with either nitropentachlorobiphenyl or nitrotrichlorodibenzo-p-dioxin. Inhibition was the primary interaction observed for the mixtures of polyhalogenated dioxins or biphenyls with the direct-acting mutagens nitrodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlorodibenzo-p-dioxin inhibited the bacterial mutagenicity of nitrodibenzo-p-dioxin by almost 50%, while pentachlorobiphenyl inhibited the mutagenicity of nitrobiphenyl by 34%. Conversely, synergism was the primary interaction observed for mixtures of halogenated aromatics with the promutagen benzo(a)pyrene. The addition of nitrotrichlorodioxin to benzo(a)pyrene enhanced the mutagenicity of the latter compound by as much as 70%, while the mutagenic potential of a mixture of benzo(a)pyrene and nitropentachlorobiphenyl was approximately 50% greater than the mutagenicity of benzo(a)pyrene alone. In summary, mixtures of nonmutagenic nitropolyhalogenated biphenyls or dibenzo-p-dioxins appear to inhibit the mutagenicity of direct-acting mutagens, while these same compounds seem to enhance the mutagenic potential of the promutagen benzo(a)pyrene.},
doi = {10.1080/15287398809531166},
url = {https://www.osti.gov/biblio/6834585}, journal = {J. Toxicol. Environ. Health; (United States)},
number = ,
volume = 24:3,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}