Three-compartmental analysis of effects of D-propranolol on thyroid hormone kinetics

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · American Journal of Physiology; (USA)

OSTI ID:6834472

Van Der Heijden, J T.M.; Krenning, E P; Van Toor, H; Hennemann, G; Docter, R ^[1]

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1. University Hospital Rotterdam (Netherlands)

Tracer thyroxine (T{sub 4}), 3,3{prime},5-triiodothyronine (T{sub 3}), and 3,3{prime},5{prime}-triiodothyronine (rT{sub 3}) kinetic studies were performed in normal T{sub 4} substituted subjects before and during oral D-propranolol treatment to determine whether changes in thyroid hormone metabolism in a propranolol-induced low-T{sub 3} syndrome result from inhibition of 5{prime}-deiodination or inhibition of transport of iodothyronines into tissues. Data were analyzed according to a three-compartmental model of distribution and metabolism. No changes were observed in size of the three T{sub 4} compartments or in fractional and mass transfer rates of T{sub 4} from plasma to the rapidly (REP) and slowly (SEP) equilibrating pools. Serum T{sub 3}, free T{sub 3}, T{sub 3} plasma pool, T{sub 3} mass transfer rate to REP and SEP, and the T{sub 3} pool masses were all significantly decreased during propranolol to a similar extent as the T{sub 3} plasma production rate (PR). It is concluded that the D-propranolol-induced changes in thyroid hormone metabolism, resulting in a low-T{sub 3} syndrome, are due to inhibition of thyroid hormone deiodination. This is in contrast to the low-T{sub 3} syndrome during caloric deprivation, which results from inhibition of transport of iodothyronines into the liver.

• OSTI ID: 6834472
• Journal Information: American Journal of Physiology; (USA), Vol. 255:1; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SYMPATHOLYTICS
BIOLOGICAL EFFECTS
THYROID HORMONES
BIOCHEMICAL REACTION KINETICS
COMPARTMENTS
IODINATION
IODINE 125
IODINE 131
MEN
METABOLISM
THYROXINE
TRIIODOTHYRONINE
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HALOGENATION
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KINETICS
MALES
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
PEPTIDE HORMONES
PRIMATES
RADIOISOTOPES
REACTION KINETICS
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques