Carbon monoxide exposure of subjects with documented cardiac arrhythmias
- St. Louis Univ. School of Medicine, MO (United States)
The impact of low-level carbon monoxide exposure on ventricular arrhythmia frequency in patients with ischemic heart disease has not been thoroughly studied. The issue is of concern because of the potential proarrhythmic effect of carbon monoxide in patients with ischemic heart disease. We studied 30 subjects with well-documented coronary artery disease who had an average of at least 30 ventricular ectopic beats per hour over a 20-hour monitoring interval. By using appropriate inclusion and exclusion criteria, subjects were selected and enrolled in a randomized double-blind study to determine the effects of carbon monoxide exposure on ventricular arrhythmia frequency at rest, during exercise, and during ambulatory activities. The carbon monoxide exposure was designed to result in 3% or 5% carboxyhemoglobin levels, as measured by gas chromatography. The carbon monoxide exposure protocol produced target levels in 60 minutes, and the levels were maintained for an additional 90 minutes to provide adequate time to assess the impact of carbon monoxide on the frequency of ventricular ectopic beats. The data on total and repetitive ventricular arrhythmias were analyzed for seven specific time intervals: (1) two hours before carbon monoxide exposure; (2) during the two-hour carbon monoxide or air exposure; (3) during a two-hour rest period; (4) during an exercise period; (5) during an exercise recovery period; (6) six hours after carbon monoxide or air exposure; and (7) approximately 10 hours after exposure, or the remaining recording interval on the Holter monitor. There was no increase in ventricular arrhythmia frequency after carbon monoxide exposure, regardless of the level of carboxyhemoglobin or the type of activity.
- OSTI ID:
- 6833559
- Journal Information:
- Research Report Health Effects Institute; (United States), Vol. 52; ISSN 1041-5505
- Country of Publication:
- United States
- Language:
- English
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BIOLOGICAL EFFECTS
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ISCHEMIA
ADULTS
AGED ADULTS
AIR POLLUTION
BLOOD PRESSURE
CARBON
CARBOXYHEMOGLOBIN
COMPARATIVE EVALUATIONS
CORONARIES
ENVIRONMENTAL EXPOSURE
EXERCISE
GAS CHROMATOGRAPHY
HEART
HOURLY VARIATIONS
HUMAN POPULATIONS
LEVELS
MONITORING
PATIENTS
PLASMA PRESSURE
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AGE GROUPS
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BODY
CARBON COMPOUNDS
CARBON OXIDES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CHROMATOGRAPHY
DISEASES
ELEMENTS
EVALUATION
HEMIC DISEASES
MAMMALS
NONMETALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
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PRIMATES
SEPARATION PROCESSES
SYMPTOMS
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560300* - Chemicals Metabolism & Toxicology