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Title: Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption

Abstract

Chromosome fragility in 96 h, low-folate cultures was found to be associated with smoking status, coffee consumption, and blood folate level. The higher proportion of cells with chromosome aberrations in cigarette smokers was attributable to lower red cell folate levels in smokers compared with nonsmokers. There was a positive linear relationship between the average cups of coffee consumed per day and the proportion of cells with aberrations. This association was independent of the effects of smoking and red cell folate level. These data suggest that smoking history, coffee consumption, and red cell folate level are important considerations for the design and interpretation of fragile site studies in cancer cytogenetics.

Authors:
; ; ; ;  [1]
  1. Centers for Disease Control, Atlanta, GA (USA)
Publication Date:
OSTI Identifier:
6833027
Resource Type:
Journal Article
Journal Name:
Environmental and Molecular Mutagenesis; (USA)
Additional Journal Information:
Journal Volume: 13:4; Journal ID: ISSN 0893-6692
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHROMOSOMAL ABERRATIONS; MUTATION FREQUENCY; COFFEE BEANS; BIOLOGICAL EFFECTS; FOLIC ACID; BIOCHEMISTRY; TOBACCO SMOKES; BEVERAGES; CYTOLOGY; DOSE-RESPONSE RELATIONSHIPS; ERYTHROCYTES; PATIENTS; AEROSOLS; AMINO ACIDS; AROMATICS; AZAARENES; BIOLOGICAL MATERIALS; BIOLOGY; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; CHEMISTRY; COLLOIDS; DISPERSIONS; DRUGS; FOOD; HEMATINICS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MATERIALS; MUTATIONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PTERIDINES; RESIDUES; SEEDS; SMOKES; SOLS; VITAMIN B GROUP; VITAMINS; 560300* - Chemicals Metabolism & Toxicology

Citation Formats

Chen, A T.L., Reidy, J A, Annest, J L, Welty, T K, and Zhou, H. Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption. United States: N. p., 1989. Web. doi:10.1002/em.2850130407.
Chen, A T.L., Reidy, J A, Annest, J L, Welty, T K, & Zhou, H. Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption. United States. https://doi.org/10.1002/em.2850130407
Chen, A T.L., Reidy, J A, Annest, J L, Welty, T K, and Zhou, H. 1989. "Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption". United States. https://doi.org/10.1002/em.2850130407.
@article{osti_6833027,
title = {Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption},
author = {Chen, A T.L. and Reidy, J A and Annest, J L and Welty, T K and Zhou, H},
abstractNote = {Chromosome fragility in 96 h, low-folate cultures was found to be associated with smoking status, coffee consumption, and blood folate level. The higher proportion of cells with chromosome aberrations in cigarette smokers was attributable to lower red cell folate levels in smokers compared with nonsmokers. There was a positive linear relationship between the average cups of coffee consumed per day and the proportion of cells with aberrations. This association was independent of the effects of smoking and red cell folate level. These data suggest that smoking history, coffee consumption, and red cell folate level are important considerations for the design and interpretation of fragile site studies in cancer cytogenetics.},
doi = {10.1002/em.2850130407},
url = {https://www.osti.gov/biblio/6833027}, journal = {Environmental and Molecular Mutagenesis; (USA)},
issn = {0893-6692},
number = ,
volume = 13:4,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}