Chromosomal aberrations and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. IV. Results with 15 chemicals

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Environmental and Molecular Mutagenesis; (USA)

DOI:https://doi.org/10.1002/em.2850140306· OSTI ID:6832987

Ivett, J L; Brown, B M; Rodgers, C ^[1]; Anderson, B E; Resnick, M A; Zeiger, E ^[2]

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1. Hazleton Labs. of America, Kensington, MD (USA)
2. National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)

The National Toxicology Program has undertaken a study to assess the ability of four genetic toxicology assays to predict the carcinogenicity of chemicals in 2-year rodent studies. Two of the assays, used for evaluating in vitro cytogenic damage, were the SCE and chromosome aberration assays in Chinese hamster ovary cells. The results and data for 15 of the chemicals tested in these two assays are presented here. Each chemical was tested with and without exogenous metabolic activation. The chemicals tested were bisphenol A, 2-chloroethanol, C.l. acid orange 10, C.l. disperse yellow 3, C.l. solvent yellow 14, cytembena, D C red 9, 1,2-dibromoethane, FD C yellow 6, malaoxon, D,L-methanol, phenol, sulfisoxazole, titanium dioxide, and tris(2-ethyl-hexyl)phosphate. In vitro cytogenetic results from the other chemicals presented by Tennant et al. have been published by Galloway et al, Gulati et al. and Loveday et. al.

• OSTI ID: 6832987
• Journal Information: Environmental and Molecular Mutagenesis; (USA), Vol. 14:3; ISSN 0893-6692
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
MUTATION FREQUENCY
MUTAGENS
GENETIC EFFECTS
SISTER CHROMATID EXCHANGES
CARCINOGENESIS
CHO CELLS
DOSE-RESPONSE RELATIONSHIPS
DYES
IN VITRO
METABOLIC ACTIVATION
PHENOL
PHENOLS
PHOSPHATES
TITANIUM OXIDES
ANIMAL CELLS
AROMATICS
BIOLOGICAL EFFECTS
CHALCOGENIDES
HYDROXY COMPOUNDS
MUTATIONS
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PATHOGENESIS
PHOSPHORUS COMPOUNDS
TITANIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
560300* - Chemicals Metabolism & Toxicology