Response of zinc, iron and copper status parameters to supplementation with zinc or zinc and iron in women

Journal Article · Wed Mar 05 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:6829560

Yadrick, K; Kenney, M A; Winterfeldt, E

Supplementation with zinc at levels available over-the-counter may compromise iron or copper status. This study examined the effects of zinc(50mg/day) or zinc and iron(50 mg each/day) on 18 women aged 25-40. Subjects were matched on initial levels of serum ferritin(SF) and erythrocyte superoxide dismutase(ESOD) and randomly assigned to Group Z (zinc) or F-Z (iron and zinc). The following were measured pretreatment and after 6 and 10 weeks treatment: serum zinc (BZ), salivary sediment zinc (SSZ), hemoglobin (Hgb), hematocrit (Hct), SF, serum ceruloplasmin (Cp) and ESOD. Effects of treatment and weeks of treatment on changes from initial blood and saliva levels were analyzed using AOV. BZ increased (P=0.0144) and ESOD decreased (P=0.0001) with weeks of treatment. Differences due to treatment are presented. No effects were noted on Hgb, Hct or Cp. Intakes of zinc supplements at about 4X RDA appear to decrease copper(ESOD) and iron(SF) status. Use of iron w/zinc may be protective for FE but not Cu, and may compromise zinc (SSZ) status.

• Research Organization: Oklahoma State Univ., Stillwater
• OSTI ID: 6829560
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ZINC
BIOLOGICAL EFFECTS
INTAKE
BLOOD COUNT
CERULOPLASMIN
COPPER
ERYTHROCYTES
HEMOGLOBIN
IRON
SUPEROXIDE DISMUTASE
WOMEN
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
COMPLEXES
COPPER COMPLEXES
ELEMENTS
ENZYMES
FEMALES
GLOBIN
GLOBULINS
GLOBULINS-ALPHA
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
MAN
MATERIALS
METALLOPROTEINS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology