Intrarenal distribution of mercury in the rat: effect of administered dose of mercuric chloride

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01606560· OSTI ID:6828454

Zalups, R K; Diamond, G L

The authors recently observed that the distribution of mercury in the hypertrophied remnant kidneys of uninephrectomized rats was different from that in the kidneys of sham-operated rats when given the same non-toxic dose of mercuric chloride (HgCl/sub 2/; 0.5 ..mu..mol/kg). These observations are quite significant, since the altered intrarenal distribution of mercury in uninephrectomized rats may cause uninephrectomized rats to develop more severe tubular necrosis in the outer medulla than sham-operated rats. In the experiments described above, the mercury burden of the hypertrophied remnant kidneys from the uninephrectomized rats was approximately twice that of each of the kidneys from the sham-operated rats. Thus, the altered intrarenal distribution of mercury in the uninephrectomized rats may be, in part, the result of the remnant kidney being exposed to more mercury. Implicit in this hypothesis is the idea that the manner in which the kidney accumulates mercury is dependent on the amount of mercury it is exposed to. If this is the case, then one would predict that the intrarenal accumulation of mercury in rats with two kidneys would change as the administered dose of HgCl/sub 2/ is increased from the dose of 0.5 ..mu..mol/kg. The principal aim of this study was to test this hypothesis.

• Research Organization: Univ. of Rochester Medical Center, NY
• OSTI ID: 6828454
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 38:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
PHYSIOLOGY
MERCURY CHLORIDES
TISSUE DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
NECROSIS
NEPHRECTOMY
RATS
ANIMALS
BODY
CHLORIDES
CHLORINE COMPOUNDS
DISTRIBUTION
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MEDICINE
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANS
PATHOLOGICAL CHANGES
RODENTS
SURGERY
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology