New selenium-75 labeled radiopharmaceuticals: selenonium analogues of dopamine

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · J. Med. Chem.; (United States)

DOI:https://doi.org/10.1021/jm00361a003· OSTI ID:6826748

Sadek, S A; Basmadjian, G P; Hsu, P M; Rieger, J A

Selenium-75 labeled selenonium analogues of dopamine, (2-(3,4-dimethoxyphenyl)ethyl)dimethylselenonium iodide and its dihydroxy analogue, were prepared by reducing (/sup 75/Se)selenious acid with sodium borohydride at pH 6.0 and reacting the NaSeH produced with 1-(3,4-dimethoxyphenyl)-2-(p-toluenesulfonyloxy)ethane. Tissue distribution studies in rats given the /sup 75/Se-labeled selenonium agents intravenously demonstrated high initial heart uptake. Prolonged adrenal retention and high adrenal to blood ratio of compound 4 were observed. The high uptake and adrenal to blood ratio suggest the potential use of compound 4 as a radiopharmaceutical for the adrenal gland.

• Research Organization: Univ. of Oklahoma, Oklahoma City
• OSTI ID: 6826748
• Journal Information: J. Med. Chem.; (United States), Vol. 26:7
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
TISSUE DISTRIBUTION
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
SELENIUM 75
ADRENAL GLANDS
RATS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
EVEN-ODD NUCLEI
GLANDS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
NEUROREGULATORS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RADIOISOTOPES
RODENTS
SELENIUM ISOTOPES
SYMPATHOMIMETICS
SYNTHESIS
VERTEBRATES
400702* - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials
550501 - Metabolism- Tracer Techniques