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Title: Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein

Abstract

The effects of cadmium on intestinal calcium absorption and calcium-binding protein (CaBP) were investigated in chicks by means of the in situ ligated duodenal loop technique. Dietary cadmium, administered in the feed or by gastric intubation, resulted in significant declines in intestinal calcium absorption and mucosal calcium-binding protein concentrations. Cadmium chloride injected directly into the ligated loop of naive chicks also diminished calcium absorption and CaBP concentrations in an apparently dose-response related fashion. No adverse effects of cadmium administration on either the 25- or 1..cap alpha..-hydroxylation reactions of vitamin D were observed. While the general effect of cadmium administration was a reduction in intestinal calcium absorption, plasma calcium levels were consistently elevated in Cd-treated chicks, with the exception of those also maintained on diets low in Ca. The results indicate that cadmium toxicity exerts at least two effects on Ca metabolism, one at the intestinal level and another at the level of the bone, kidney, or both.

Authors:
; ;
Publication Date:
Research Org.:
Cornell Univ., Ithaca, NY
OSTI Identifier:
6816832
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 22:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CADMIUM; BIOLOGICAL EFFECTS; CALCIUM; INTESTINAL ABSORPTION; CHICKENS; EXPERIMENTAL DATA; INFANTS; INGESTION; PROTEINS; QUANTITY RATIO; TOXICITY; VITAMIN D; ABSORPTION; AGE GROUPS; ALKALINE EARTH METALS; ANIMALS; BIRDS; CHILDREN; DATA; ELEMENTS; FOWL; INFORMATION; INTAKE; MAMMALS; MAN; METALS; NEONATES; NUMERICAL DATA; ORGANIC COMPOUNDS; PRIMATES; UPTAKE; VERTEBRATES; VITAMINS; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Fullmer, C S, Oku, T, and Wasserman, R H. Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein. United States: N. p., 1980. Web. doi:10.1016/0013-9351(80)90150-4.
Fullmer, C S, Oku, T, & Wasserman, R H. Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein. United States. https://doi.org/10.1016/0013-9351(80)90150-4
Fullmer, C S, Oku, T, and Wasserman, R H. 1980. "Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein". United States. https://doi.org/10.1016/0013-9351(80)90150-4.
@article{osti_6816832,
title = {Effect of cadmium administration on intestinal calcium absorption and vitamin D-dependent calcium-binding protein},
author = {Fullmer, C S and Oku, T and Wasserman, R H},
abstractNote = {The effects of cadmium on intestinal calcium absorption and calcium-binding protein (CaBP) were investigated in chicks by means of the in situ ligated duodenal loop technique. Dietary cadmium, administered in the feed or by gastric intubation, resulted in significant declines in intestinal calcium absorption and mucosal calcium-binding protein concentrations. Cadmium chloride injected directly into the ligated loop of naive chicks also diminished calcium absorption and CaBP concentrations in an apparently dose-response related fashion. No adverse effects of cadmium administration on either the 25- or 1..cap alpha..-hydroxylation reactions of vitamin D were observed. While the general effect of cadmium administration was a reduction in intestinal calcium absorption, plasma calcium levels were consistently elevated in Cd-treated chicks, with the exception of those also maintained on diets low in Ca. The results indicate that cadmium toxicity exerts at least two effects on Ca metabolism, one at the intestinal level and another at the level of the bone, kidney, or both.},
doi = {10.1016/0013-9351(80)90150-4},
url = {https://www.osti.gov/biblio/6816832}, journal = {Environ. Res.; (United States)},
number = ,
volume = 22:2,
place = {United States},
year = {Fri Aug 01 00:00:00 EDT 1980},
month = {Fri Aug 01 00:00:00 EDT 1980}
}