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Title: Development of pulmonary vascular response to oxygen

Abstract

The ability of the pulmonary circulation of the fetal lamb to respond to a rise in oxygen tension was studied from 94 to 146 days of gestation. The unanesthetized ewe breathed room air at normal atmospheric pressure, followed by 100% oxygen at three atmospheres absolute pressure in a hyperbaric chamber. In eleven near-term lambs, fetal arterial oxygen tension (Pa{sub O{sub 2}}) increased from 25 to 55 Torr, which increased the proportion or right ventricular output distributed to the fetal lungs from 8 to 59%. In five very immature lambs fetal Pa{sub O{sub 2}} increased from 27 to 174 Torr, but the proportion of right ventricular output distributed to the lung did not change. In five of the near-term lambs, pulmonary blood flow was measured. For each measurement of the distribution of blood flow, approximately 8 {times} 10{sup 5} spheres of 15-{mu}m diameter, labeled with either {sup 153}Gd, {sup 113}Sn, {sup 103}Ru, {sup 95}Nb, or {sup 46}Sc were injected. It increased from 34 to 298 ml {center dot} kg fetal wt{sup {minus}1} {center dot} min{sup {minus}1}, an 8.8-fold increase. The authors conclude that the pulmonary circulation of the fetal lamb does not respond to an increase in oxygen tension before 101more » days of gestation; however, near term an increase in oxygen tension alone can induce the entire increase in pulmonary blood flow that normally occurs after the onset of breathing at birth.« less

Authors:
;  [1]
  1. State Univ. of New York, Buffalo (USA)
Publication Date:
OSTI Identifier:
6808837
Resource Type:
Journal Article
Journal Name:
American Journal of Physiology; (USA)
Additional Journal Information:
Journal Volume: 254:3; Journal ID: ISSN 0002-9513
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD FLOW; RADIOASSAY; LUNGS; BLOOD CIRCULATION; BLOOD PRESSURE; GADOLINIUM 153; MICROSPHERES; NIOBIUM 95; OXYGEN; PHYSIOLOGY; RUTHENIUM 103; SCANDIUM 46; SHEEP; TIN 113; VASOCONSTRICTION; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DOMESTIC ANIMALS; ELECTRON CAPTURE RADIOISOTOPES; ELEMENTS; EVEN-ODD NUCLEI; GADOLINIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NIOBIUM ISOTOPES; NONMETALS; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANS; RADIOISOTOPES; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; RESPIRATORY SYSTEM; RUMINANTS; RUTHENIUM ISOTOPES; SCANDIUM ISOTOPES; SECONDS LIVING RADIOISO; TIN ISOTOPES; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques

Citation Formats

Morin, F.C. III, Egan, E.A., Ferguson, W, and Lundgren, C E. Development of pulmonary vascular response to oxygen. United States: N. p., 1988. Web.
Morin, F.C. III, Egan, E.A., Ferguson, W, & Lundgren, C E. Development of pulmonary vascular response to oxygen. United States.
Morin, F.C. III, Egan, E.A., Ferguson, W, and Lundgren, C E. 1988. "Development of pulmonary vascular response to oxygen". United States.
@article{osti_6808837,
title = {Development of pulmonary vascular response to oxygen},
author = {Morin, F.C. III, Egan, E.A. and Ferguson, W and Lundgren, C E},
abstractNote = {The ability of the pulmonary circulation of the fetal lamb to respond to a rise in oxygen tension was studied from 94 to 146 days of gestation. The unanesthetized ewe breathed room air at normal atmospheric pressure, followed by 100% oxygen at three atmospheres absolute pressure in a hyperbaric chamber. In eleven near-term lambs, fetal arterial oxygen tension (Pa{sub O{sub 2}}) increased from 25 to 55 Torr, which increased the proportion or right ventricular output distributed to the fetal lungs from 8 to 59%. In five very immature lambs fetal Pa{sub O{sub 2}} increased from 27 to 174 Torr, but the proportion of right ventricular output distributed to the lung did not change. In five of the near-term lambs, pulmonary blood flow was measured. For each measurement of the distribution of blood flow, approximately 8 {times} 10{sup 5} spheres of 15-{mu}m diameter, labeled with either {sup 153}Gd, {sup 113}Sn, {sup 103}Ru, {sup 95}Nb, or {sup 46}Sc were injected. It increased from 34 to 298 ml {center dot} kg fetal wt{sup {minus}1} {center dot} min{sup {minus}1}, an 8.8-fold increase. The authors conclude that the pulmonary circulation of the fetal lamb does not respond to an increase in oxygen tension before 101 days of gestation; however, near term an increase in oxygen tension alone can induce the entire increase in pulmonary blood flow that normally occurs after the onset of breathing at birth.},
doi = {},
url = {https://www.osti.gov/biblio/6808837}, journal = {American Journal of Physiology; (USA)},
issn = {0002-9513},
number = ,
volume = 254:3,
place = {United States},
year = {Tue Mar 01 00:00:00 EST 1988},
month = {Tue Mar 01 00:00:00 EST 1988}
}