Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases
Abstract
Proton beam therapy for uveal malignant melanoma has been advocated as effective therapy because of documented reduction in tumor size and few clinical complications. However, some eyes have been removed because of adverse effects. The authors report the clinical courses and pathologic findings of five eyes enucleated after proton beam irradiation. Neovascular glaucoma had developed in three eyes, two eyes had vitreous hemorrhage, and two had extraocular extension. The tumors in the radiation treatment field showed continued postirradiation growth clinically in four of the five eyes, and mitotic activity histologically in all five cases. Two and one half years after irradiation, and nearly 2 years after subsequent enucleation, one of those two patients had biopsy-proven liver metastases, and later died. Despite the considerable success rate of proton beam irradiation, the potential for clinical complications and subsequent tumor growth remains.
- Authors:
- Publication Date:
- Research Org.:
- Univ. of Texas Health Science Center, San Antonio (USA)
- OSTI Identifier:
- 6797107
- Resource Type:
- Journal Article
- Journal Name:
- Ophthalmology (Rochester, Minn.); (United States)
- Additional Journal Information:
- Journal Volume: 95:7
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MELANOMAS; RADIOTHERAPY; SIDE EFFECTS; UVEA; BIOLOGICAL RADIATION EFFECTS; HEMORRHAGE; MITOSIS; PATIENTS; PROTON BEAMS; RADIATION INJURIES; BEAMS; BIOLOGICAL EFFECTS; BODY; BODY AREAS; CELL DIVISION; DISEASES; EYES; FACE; HEAD; INJURIES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; NUCLEON BEAMS; ORGANS; PARTICLE BEAMS; PATHOLOGICAL CHANGES; RADIATION EFFECTS; RADIOLOGY; SENSE ORGANS; SYMPTOMS; THERAPY; 560151* - Radiation Effects on Animals- Man
Citation Formats
Kincaid, M C, Folberg, R, Torczynski, E, Zakov, Z N, Shore, J W, Liu, S J, Planchard, T A, and Weingeist, T A. Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases. United States: N. p., 1988.
Web. doi:10.1016/S0161-6420(88)33092-7.
Kincaid, M C, Folberg, R, Torczynski, E, Zakov, Z N, Shore, J W, Liu, S J, Planchard, T A, & Weingeist, T A. Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases. United States. https://doi.org/10.1016/S0161-6420(88)33092-7
Kincaid, M C, Folberg, R, Torczynski, E, Zakov, Z N, Shore, J W, Liu, S J, Planchard, T A, and Weingeist, T A. 1988.
"Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases". United States. https://doi.org/10.1016/S0161-6420(88)33092-7.
@article{osti_6797107,
title = {Complications after proton beam therapy for uveal malignant melanoma. A clinical and histopathologic study of five cases},
author = {Kincaid, M C and Folberg, R and Torczynski, E and Zakov, Z N and Shore, J W and Liu, S J and Planchard, T A and Weingeist, T A},
abstractNote = {Proton beam therapy for uveal malignant melanoma has been advocated as effective therapy because of documented reduction in tumor size and few clinical complications. However, some eyes have been removed because of adverse effects. The authors report the clinical courses and pathologic findings of five eyes enucleated after proton beam irradiation. Neovascular glaucoma had developed in three eyes, two eyes had vitreous hemorrhage, and two had extraocular extension. The tumors in the radiation treatment field showed continued postirradiation growth clinically in four of the five eyes, and mitotic activity histologically in all five cases. Two and one half years after irradiation, and nearly 2 years after subsequent enucleation, one of those two patients had biopsy-proven liver metastases, and later died. Despite the considerable success rate of proton beam irradiation, the potential for clinical complications and subsequent tumor growth remains.},
doi = {10.1016/S0161-6420(88)33092-7},
url = {https://www.osti.gov/biblio/6797107},
journal = {Ophthalmology (Rochester, Minn.); (United States)},
number = ,
volume = 95:7,
place = {United States},
year = {Fri Jul 01 00:00:00 EDT 1988},
month = {Fri Jul 01 00:00:00 EDT 1988}
}