skip to main content

Title: Removal of. cap alpha. -tocopherol from blood and its comparison with other lipids

The blood decay curve of ..cap alpha..-tocopherol in rats was compared with those of the two major blood lipids by labeling rat serum in vitro with /sup 3/H-..cap alpha..-tocopherol (AT), /sup 3/H-cholesterol (CHO) or /sup 3/H-trioleoylglycerol (TO) and injecting it into the bloodstream. For the three lipids, loss from blood was biphasic. The half time of the faster decay was 2-4 minutes. The slower curve decayed with half times of 42, 289 and 990 minutes for TO, AT and CHO, respectively. This intermediate rate of AT removal is consistent with its accompanying both of the major blood lipids as they are removed by their respective mechanisms or with a process specific for AT. To investigate the role of liver in the faster curve, animals were hepatectomized. TO and CHO loss remained biphasic after liver removal. However, AT loss became monophasic, with a loss rate intermediate between the non-hepatectomized fast and slow decays. This demonstrates a central role for liver in the metabolism of blood-borne AT and a mode of removal distinct from the other two lipids.
Authors:
; ;
Publication Date:
OSTI Identifier:
6796989
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA; TRN: 87-010545
Resource Type:
Journal Article
Resource Relation:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Research Org:
Univ. of Rochester, NY
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; VITAMIN E; BLOOD-PLASMA CLEARANCE; METABOLISM; BIOLOGICAL HALF-LIFE; CHOLESTEROL; COMPARATIVE EVALUATIONS; TRACER TECHNIQUES; TRIGLYCERIDES; TRITIUM COMPOUNDS; CLEARANCE; ESTERS; HYDROXY COMPOUNDS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; LIPIDS; ORGANIC COMPOUNDS; STEROIDS; STEROLS; VITAMINS 550501* -- Metabolism-- Tracer Techniques