Abdominal irradiation in the treatment of Wilms' tumor
One hundred and fifty-two consecutive children who had Wilms' tumor were treated from 1960 to 1976. This series was analysed to determine the effect of systemic treatment on the incidence of abdominal relapse. Primary treatment included abdominal irradiation in 151 of these patients. Twenty-two patients (14%) had abdominal disease alone or in part at first relapse. For stages I-IV combined, a first abdominal relapse within the irradiated volume occurred in 3/21 patients (14%) who received no systemic treatment; 6/83 patients (7%) who received actinomycin D (AMD) and 1/35 patients (3%) who received AMD and vincristine (VCR). The mean radiation dose, 2400 rad given in 100-125 rad fractions, was essentially constant. Overall two in-field abdominal relapses occurred among 85 patients with stage I or II disease. The optimal radiation dose could not be determined in this retrospective review, but for stages I and II it was not greater than 2400 rad in 24 fractions.
- Research Organization:
- Ontario Cancer Inst., Canada
- OSTI ID:
- 6793741
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:6
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CHILDREN
BIOLOGICAL RADIATION EFFECTS
LIVER
NEOPLASMS
ABDOMEN
ACTINOMYCIN
COBALT 60
FRACTIONATED IRRADIATION
ONCOVIN
PARTIAL BODY IRRADIATION
PATIENTS
PEDIATRICS
RADIATION DOSES
RADIOSENSITIVITY EFFECTS
AGE GROUPS
ALKALOIDS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOSES
DRUGS
EXTERNAL IRRADIATION
GLANDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
551000 - Physiological Systems