Suppressor cell activity following total lymphoid irradiation (TLI), bone marrow (BM) injection, and kidney transplantation in baboons

Conference · Sun Mar 01 00:00:00 EST 1981 · Transplant. Soc., Int. Cong., Proc.; (United States)

OSTI ID:6792649

Smit, J A; Myburgh, J A; Hill, R R.H.; Browde, S

Induction of specific tissue transplantation tolerance by fractionated TLI was first described in adult mice, rats, and dogs. The method was equally effective in inducing unresponsiveness in outbred baboons, and irradiation given in fractions was confirmed to be more efficient than single dose. This study investigated the cumulative effect of 600 to 2400 rad TLI on the immune response of baboons treated according to a schedule applicable to patients awaiting renal transplantation. The possible mechanisms involved in tolerogenesis include the following: broad nonspecific nonreactivity, clonal deletion, suppressor cell activity, and enhancement.

• Research Organization: Univ. of Witwatersrand, Johannesburg, South Africa
• OSTI ID: 6792649
• Journal Information: Transplant. Soc., Int. Cong., Proc.; (United States), Vol. 13:1; Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 5 Jul 1980
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNITY
BIOLOGICAL RADIATION EFFECTS
IMMUNOSUPPRESSION
RADIOINDUCTION
LYMPHOCYTES
EVALUATION
MITOGENS
TOLERANCE
APES
BONE MARROW CELLS
FRACTIONATED IRRADIATION
KIDNEYS
LYMPH NODES
PARTIAL BODY IRRADIATION
SURVIVAL TIME
TRANSPLANTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
EXTERNAL IRRADIATION
IRRADIATION
LEUKOCYTES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
ORGANS
PRIMATES
RADIATION EFFECTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals