Combination radiation-adriamycin therapy: renoprival growth, functional and structural effects in the immature mouse

Conference · Tue Jul 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6792050

Donaldson, S S; Moskowitz, P S; Canty, E L; Fajardo, L F

The normal tissue effects of radiation-adriamycin combination therapy were studied in the renoprival weanling mouse in an attempt to determine whether compensatory renal growth inhibition from radiation and chemotherapy could be associated with structural or functional abnormalities. Weanling BLc/sub Fl/ mice underwent unilateral nephrectomy, then single fraction renal irradiation, LD 1/21 doses of adriamycin in 5 daily doses, or combination therapy with radiation and adriamycin. Animals were sacrificed at 3, 12, and 24 weeks. Compensatory renal growth, body growth, serum blood urea nitrogen (BUN), and renal morphology by light microscopy were evaluated. Significant compensatory renal growth inhibition from radiation-adriamycin therapy exceeded that produced by adriamycin alone and radiation alone, at all time periods (p < 0.005). Body growth inhibition from radiation-adriamycin therapy or adriamycin alone significantly exceeded that produced by radiation alone (p < 0.005). Kidney and body growth inhibition from radiation-adriamycin therapy was proportionately severe. Kidney growth inhibition proportionately exceeded body growth inhibition with radiation alone; body growth inhibition proportionately exceeded kidney growth inhibition with adriamycin alone. Comparable azotemia developed by 24 weeks in both the radiation alone (p < .005) and radiation-adriamycin animals (p < 0.005), but not in the adriamycin only animals. Morphologic alterations consisting of increased glomerular density, tubular atrophy, and stromal fibrosis occurred with greater severity in the radiation-adriamycin animals than in the radiation only animals by 24 weeks; no alterations were seen in the adriamycin only animals. Using histologic criteria 750 rad plus adriamycin produced comparable injury as seen with 1000 rad alone, thus adriamycin produced an apparent dose-modifying factor of 1.33.

• Research Organization: Stanford Univ. School of Medicine, CA
• OSTI ID: 6792050
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:7; Conference: 6. international congress of radiation research, Tokyo, Japan, May 13, 1979
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
DOXORUBICIN
RADIOSENSITIVITY EFFECTS
GLOMERULI
BIOLOGICAL RADIATION EFFECTS
GROWTH
MICE
TUBULES
ATROPHY
BIOCHEMISTRY
INHIBITION
LOCAL IRRADIATION
NEONATES
QUANTITATIVE CHEMICAL ANALYSIS
RADIATION DOSES
RADIOINDUCTION
RESPONSE MODIFYING FACTORS
ULTRASTRUCTURAL CHANGES
URINE
X RADIATION
ANIMALS
ANTIBIOTICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHEMICAL ANALYSIS
CHEMISTRY
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
KIDNEYS
MAMMALS
MATERIALS
MORPHOLOGICAL CHANGES
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
WASTES
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
551000 - Physiological Systems