Glyoxylic compounds as radiosensitizers of hypoxic cells

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Biochemical Medicine and Metabolic Biology; (USA)

DOI:https://doi.org/10.1016/0885-4505(90)90032-V· OSTI ID:6790292

Cornago, M P; Lopez Zumel, M C; Alvarez, M V; Izquierdo, M C ^[1]

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1. Instituto Quimica Fisica Rocasolano, CSIC, Madrid (Spain)

The radiosensitizing effect of five glyoxal derivatives on the survival of TC-SV40 cells has been measured, under aerobic and hypoxic conditions. A toxicity study was previously performed in order to use nontoxic concentrations. The OER for the TC-SV40 cells was 2.74. None of the glyoxylic compounds showed radiosensitizing activity under aerobic conditions while in hypoxia their radiosensitizing factors decreased in the order phenylglyoxylic acid (1.68 at 8 x 10(-3) mole dm-3) greater than phenylglyoxal (1.55 at 5 x 10(-6) mole dm-3) greater than 2-2' furil (1.48 at 5 x 10(-5) mole dm-3) greater than glyoxylic acid (1.39 at 1 x 10(-3) mole dm-3) greater than glyoxal (1.30 at 5 x 10(-5) mole dm-3). The dose-modifying factors were also determined at two equimolar concentrations 5 x 10(-5) and 5 x 10(-6) mole dm-3. A concentration effect was noticed for all the compounds although their relative radiosensitizing activity kept, independently of the concentration, the same order noted above. Glyoxals with aromatic or heterocyclic rings exert a greater radiosensitization than the others. The acidic compounds have less radiosensitizing activity than their aldehydic counterparts. Interaction of these glyoxals with NPSH cellular groups was tested and the low degree of inhibition shows that this mechanism would contribute very little, if any, to the radiosensitization effect.

• OSTI ID: 6790292
• Journal Information: Biochemical Medicine and Metabolic Biology; (USA), Vol. 43:3; ISSN 0885-4505
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
GLYOXYLIC ACID
RADIOSENSITIVITY EFFECTS
ANOXIA
MOLECULAR STRUCTURE
RADIOSENSITIZERS
SURVIVAL TIME
TUMOR CELLS
ALDEHYDES
ANIMAL CELLS
CARBOXYLIC ACIDS
DRUGS
ORGANIC ACIDS
ORGANIC COMPOUNDS
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
550603 - Medicine- External Radiation in Therapy- (1980-)