The inhibitory effect of ionizing radiation on Fc and C3 receptors on mouse and human leukocytes, and the protective potential of human albumin

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Experimental Hematology (Lawrence, Kansas); (USA)

OSTI ID:6789698

Herrera, M A; Diaz-Perches, R; Gutierrez, M; Gamminio, E; Liera, C; Nieto, P; Weiss-Steider, B ^[1]

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1. National Univ. of Mexico, Mexico City (Mexico)

The effect that ionizing radiation has in vitro on Fc and C3 receptors was evaluated at various doses and measured by means of erythrocytes coated with antibody (EA) and erythrocytes coated with antibody and complement (EAC) rosettes on human peripheral blood leukocytes (PBL) and on mouse bone marrow cells (BMC) and PBL. We found that the number of cells with either EA and EAC rosettes decreased as the radiation doses increased, and that they were almost absent when the highest doses were employed. We obtained evidence that albumin is a natural source of radio-protection for Fc and C3 receptors, and we showed that by increasing the amount of this molecule we could completely protect receptors for EA and EAC in vitro. Finally, the possible therapeutic value of the administration of human albumin to patients undergoing radiotherapy is discussed.

• OSTI ID: 6789698
• Journal Information: Experimental Hematology (Lawrence, Kansas); (USA), Vol. 18:7; ISSN 0301-472X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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RADIOSENSITIVITY EFFECTS
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RECEPTORS
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MAMMALS
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ORGANIC COMPOUNDS
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