Absorption, retention, and utilization of two forms of selenium given simultaneously as stable isotope tracers to lactating and nonlactating women

Miscellaneous · Sun Jan 01 00:00:00 EST 1989

OSTI ID:6787274

Mangels, A R

We investigated absorption, retention, and utilization of selenomethionine (SeMet) and selenite (SeO{sub 3}) in 6 lactating and 6 nonlactating women, 2 to 3 mo postpartum, and 7 never pregnant women. Subjects were maintained on controlled diets for 3 wk. After 1 wk equilibration, subjects received simultaneous oral doses of {sup 74}Se L-SeMet and {sup 76}Se SeO{sub 3}. Complete urine and fecal collections were made for 1 d prior to and 2 wk after isotope dosing. Lactating women collected milk samples from all feedings for 24 h before and 48 h after isotopes. Blood was collected from subjects before isotope dosing and 2,24, 168, and 336 h later. All samples were analyzed for natural Se, {sup 74}Se, and {sup 76}Se by isotope dilution mass spectrometry.

• Research Organization: Maryland Univ., College Park, MD (USA)
• OSTI ID: 6787274
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
SELENIUM
METABOLISM
INTESTINAL ABSORPTION
ISOTOPE DILUTION
LACTATION
PREGNANCY
RETENTION
SELENIUM 74
SELENIUM 76
ABSORPTION
ELEMENTS
EVEN-EVEN NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
SELENIUM ISOTOPES
SEMIMETALS
STABLE ISOTOPES
TRACER TECHNIQUES
UPTAKE
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques