Use of (/sup 99m/Tc)-HM-PAO in the diagnosis of primary degenerative dementia
The clinical value of single photon emission computed tomography (SPECT) in the differential diagnosis of dementia due to cerebral atrophy was evaluated by comparing the pattern of distribution (/sup 99m/Tc)-HM-PAO in three dementing conditions. Imaging was carried out in 26 patients with suspected Alzheimer's disease, 14 with dementia of the frontal-lobe type, and 13 with progressive supranuclear palsy. Images were evaluated and reported without knowledge of clinical diagnosis with respect to regions of reduced uptake of tracer. Reduced uptake in the posterior cerebral hemispheres was characteristic of Alzheimer's disease, while selective anterior hemisphere abnormalities characterized both dementia of the frontal-lobe type and progressive supranuclear palsy. The latter conditions could be distinguished on the basis of the appearance of integrity of the rim of the frontal cortex. The technique has an important role in the differentiation of degenerative dementias.
- Research Organization:
- Manchester Royal Infirmary (England)
- OSTI ID:
- 6786254
- Journal Information:
- J. Cereb. Blood Flow Metab.; (United States), Vol. 8:6
- Country of Publication:
- United States
- Language:
- English
Similar Records
CBF tomograms with (/sup 99m/Tc-HM-PAO in patients with dementia (Alzheimer type and HIV) and Parkinson's disease--initial results
Regional cerebral blood flow study with 123I-IMP in patients with degenerative dementia
Related Subjects
BRAIN
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
NERVOUS SYSTEM DISEASES
DIAGNOSIS
RADIOPHARMACEUTICALS
UPTAKE
ATROPHY
ISOMERIC NUCLEI
ORGANOMETALLIC COMPOUNDS
OXIMES
PATIENTS
TECHNETIUM 99
AMINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPES
TECHNETIUM ISOTOPES
TOMOGRAPHY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics