Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electrical field
The authors have investigated in vitro the effects of the electrical field produced by constant current on freshly isolated rabbit osteoclasts and on well characterized clonal rat osteoblastlike cells. At field strengths of 0.1 and 1 V/mm, the osteoclasts migrated rapidly toward the positive electrode, whereas the osteoblastlike cells migrated in the opposite direction, toward the negative electrode. Thus, different cell types from the same tissue can respond differently to the same electrical signal. These results have important implications for hypotheses concerning the cellular mechanism of galvanotaxis, and may also clarify the cellular basis of the clinical application of electrical stimulation of bone healing.
- Research Organization:
- Univ. of Toronto, Ontario
- OSTI ID:
- 6784959
- Journal Information:
- J. Cell. Physiol.; (United States), Vol. 129:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE FRACTURES
HEALING
ELECTRIC FIELDS
BIOLOGICAL EFFECTS
BONE CELLS
MIGRATION
RABBITS
SKELETON
ANIMAL CELLS
ANIMALS
BIOLOGICAL RECOVERY
BODY
CONNECTIVE TISSUE CELLS
INJURIES
MAMMALS
ORGANS
RECOVERY
SOMATIC CELLS
VERTEBRATES
560400* - Other Environmental Pollutant Effects