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Title: Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose

Abstract

A high degree of immunity, as shown by a 91% reduction of the number of worms recovered was found in five groups of mice that were immunized five times with highly X-irradiated cercariae and then challenged with 10, 20, 50, 100, or 500 normal Schistosoma mansoni cercariae. The results indicated that there were no significant differences in worm reduction in immunized mice challenged with different numbers of cercariae; consequently the immunity induced by this immunization method did not appear to be challenge-dose-dependent. However, the results also showed that when immunized mice were challenged with 500, 100, 50, 20, and 10 cercariae, 0, 13, 26, 56, and 68%, respectively, of the experimental animals were free of worms. Thus, the percentage of worm-negative cases increased as the number of challenge cercariae decreased. When viewed in this manner, the acquired immunity may be considered challenge-dose-dependent as well. If this method of vaccination is used for schistosomiasis control, we may anticipate that in both hypo- and hyperendemic areas, the intensity of infection and the severity of the disease will be reduced owing to a reduction in worms burdens, and in hypoendemic areas, there will be a number of worm-free cases.

Authors:
; ; ;
Publication Date:
Research Org.:
Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City
OSTI Identifier:
6782667
Resource Type:
Journal Article
Journal Name:
J. Parasitol.; (United States)
Additional Journal Information:
Journal Volume: 68:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; SCHISTOSOMA; BIOLOGICAL RADIATION EFFECTS; SCHISTOSOMIASIS; VACCINES; DOSE-RESPONSE RELATIONSHIPS; IMMUNITY; INOCULATION; MICE; PREVENTIVE MEDICINE; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; DISEASES; ELECTROMAGNETIC RADIATION; HELMINTHS; INFECTIOUS DISEASES; IONIZING RADIATIONS; MAMMALS; MEDICINE; PARASITIC DISEASES; PLATYHELMINTHS; RADIATION EFFECTS; RADIATIONS; RODENTS; TREMATODES; VERTEBRATES; 560134* - Radiation Effects on Microorganisms- Vaccine Preparation & Other Applications- (-1987)

Citation Formats

Hsue, S Y, Hsue, H F, Osborne, J W, and Johnson, S C. Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose. United States: N. p., 1982. Web. doi:10.2307/3281174.
Hsue, S Y, Hsue, H F, Osborne, J W, & Johnson, S C. Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose. United States. https://doi.org/10.2307/3281174
Hsue, S Y, Hsue, H F, Osborne, J W, and Johnson, S C. 1982. "Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose". United States. https://doi.org/10.2307/3281174.
@article{osti_6782667,
title = {Schistosoma mansoni: is acquired immunity induced by highly x-irradiated cercariae dependent on the size of the challenging dose},
author = {Hsue, S Y and Hsue, H F and Osborne, J W and Johnson, S C},
abstractNote = {A high degree of immunity, as shown by a 91% reduction of the number of worms recovered was found in five groups of mice that were immunized five times with highly X-irradiated cercariae and then challenged with 10, 20, 50, 100, or 500 normal Schistosoma mansoni cercariae. The results indicated that there were no significant differences in worm reduction in immunized mice challenged with different numbers of cercariae; consequently the immunity induced by this immunization method did not appear to be challenge-dose-dependent. However, the results also showed that when immunized mice were challenged with 500, 100, 50, 20, and 10 cercariae, 0, 13, 26, 56, and 68%, respectively, of the experimental animals were free of worms. Thus, the percentage of worm-negative cases increased as the number of challenge cercariae decreased. When viewed in this manner, the acquired immunity may be considered challenge-dose-dependent as well. If this method of vaccination is used for schistosomiasis control, we may anticipate that in both hypo- and hyperendemic areas, the intensity of infection and the severity of the disease will be reduced owing to a reduction in worms burdens, and in hypoendemic areas, there will be a number of worm-free cases.},
doi = {10.2307/3281174},
url = {https://www.osti.gov/biblio/6782667}, journal = {J. Parasitol.; (United States)},
number = ,
volume = 68:2,
place = {United States},
year = {Thu Apr 01 00:00:00 EST 1982},
month = {Thu Apr 01 00:00:00 EST 1982}
}