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Title: T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt

Abstract

Portosystemic shunt is one of the most important complications of liver cirrhosis. Unfortunately, current methods for detecting and quantifying this shunt are either non-specific or associated with significant morbidity. The aim of this work was to evaluate the clinical value of a new non-traumatic method which consisted of administrating T1-201 per rectum and monitoring the absorbed activity using a camera and a computer system. The method assumes that in the absence of portosystemic shunt, most of the absorbed activity will be fixed in the liver while in the presence of this shunt, some of the activity will be fixed in the myocardium. The ratio of heart to liver activity can therefore be used to evaluate the importance of the portosystemic shunt. 34 subjects have been studied. The ratio of heart to liver activity at the 25th minute after the tracer administration is higher in patients with liver cirrhosis (n=22, m=.9, s.d.=.37) than in patients with steatosis (n=10, m=.28, s.d.=.03). In two healthy subjects investigated the H/L ratio was .27 and .30. The reproducibility of the test was evaluated in 8 subjects and showed a good reproducibility (mean of difference =.03, range=.01 to .07). Patients with esophageal varices had always amore » high H/L ratio while some patients with liver cirrhosis without esophageal varices had also high H/L ratio, probably due to the presence of intrahepatic shunt. The authors' results showed the value of this new non-traumatic test for detecting and quantifying extra- as well as intrahepatic portosystematic shunt.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Dept. Radioisotopes and Gastroenterology, St. Peter Hospital, Free Univ. of Brussels
OSTI Identifier:
6781428
Report Number(s):
CONF-840619-
Journal ID: CODEN: JNMEA; TRN: 87-008805
Resource Type:
Conference
Journal Name:
J. Nucl. Med.; (United States)
Additional Journal Information:
Journal Volume: 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LIVER CIRRHOSIS; PATHOLOGICAL CHANGES; PORTAL SYSTEM; VASCULAR DISEASES; THALLIUM 201; INTESTINAL ABSORPTION; DIAGNOSIS; DIAGNOSTIC USES; ESOPHAGUS; LIVER; MYOCARDIUM; PATIENTS; RECTUM; TRACER TECHNIQUES; ABSORPTION; BETA DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DIGESTIVE SYSTEM DISEASES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; GASTROINTESTINAL TRACT; GLANDS; HEART; HEAVY NUCLEI; INTESTINES; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; LARGE INTESTINE; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; UPTAKE; USES; VEINS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Verdickt, X, Reding, P, Tshiamala, P, and Ham, H R. T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt. United States: N. p., 1984. Web.
Verdickt, X, Reding, P, Tshiamala, P, & Ham, H R. T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt. United States.
Verdickt, X, Reding, P, Tshiamala, P, and Ham, H R. 1984. "T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt". United States.
@article{osti_6781428,
title = {T1-201 per rectum: A noninvasive method for evaluating portosystemic shunt},
author = {Verdickt, X and Reding, P and Tshiamala, P and Ham, H R},
abstractNote = {Portosystemic shunt is one of the most important complications of liver cirrhosis. Unfortunately, current methods for detecting and quantifying this shunt are either non-specific or associated with significant morbidity. The aim of this work was to evaluate the clinical value of a new non-traumatic method which consisted of administrating T1-201 per rectum and monitoring the absorbed activity using a camera and a computer system. The method assumes that in the absence of portosystemic shunt, most of the absorbed activity will be fixed in the liver while in the presence of this shunt, some of the activity will be fixed in the myocardium. The ratio of heart to liver activity can therefore be used to evaluate the importance of the portosystemic shunt. 34 subjects have been studied. The ratio of heart to liver activity at the 25th minute after the tracer administration is higher in patients with liver cirrhosis (n=22, m=.9, s.d.=.37) than in patients with steatosis (n=10, m=.28, s.d.=.03). In two healthy subjects investigated the H/L ratio was .27 and .30. The reproducibility of the test was evaluated in 8 subjects and showed a good reproducibility (mean of difference =.03, range=.01 to .07). Patients with esophageal varices had always a high H/L ratio while some patients with liver cirrhosis without esophageal varices had also high H/L ratio, probably due to the presence of intrahepatic shunt. The authors' results showed the value of this new non-traumatic test for detecting and quantifying extra- as well as intrahepatic portosystematic shunt.},
doi = {},
url = {https://www.osti.gov/biblio/6781428}, journal = {J. Nucl. Med.; (United States)},
number = ,
volume = 25:5,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1984},
month = {Sun Jan 01 00:00:00 EST 1984}
}

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