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Title: Epidemiological studies on radiation carcinogenesis in human populations following acute exposure: nuclear explosions and medical radiation

The present review provides an understanding of our current knowledge of the carcinogenic effect of low-dose radiation in man, and surveys the epidemiological studies of human populations exposed to nuclear explosions and medical radiation. Discussion centers on the contributions of quantitative epidemiology to present knowledge, the reliability of the dose-incidence data, and those relevant epidemiological studies that provide the most useful information for risk estimation of cancer-induction in man. Reference is made to dose-incidence relationships from laboratory animal experiments where they may obtain for problems and difficulties in extrapolation from data obtained at high doses to low doses, and from animal data to the human situation. The paper describes the methods of application of such epidemiological data for estimation of excess risk of radiation-induced cancer in exposed human populations, and discusses the strengths and limitations of epidemiology in guiding radiation protection philosophy and public health policy.
Authors:
Publication Date:
OSTI Identifier:
6778087
Report Number(s):
LBL-13416-Rev.; CONF-8105130-1-Rev.
ON: DE82022058; TRN: 82-022896
DOE Contract Number:
AC03-76SF00098
Resource Type:
Conference
Resource Relation:
Conference: Symposium on effects on humans of exposure to low levels of ionizing radiation, New Haven, CT, USA, 11 May 1981
Research Org:
Lawrence Berkeley Lab., CA (USA); California Univ., Berkeley (USA). Donner Lab.; California Univ., San Francisco (USA). Dept. of Radiology
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HUMAN POPULATIONS; EPIDEMIOLOGY; LOW DOSE IRRADIATION; CARCINOGENESIS; RISK ASSESSMENT; DOSE-RESPONSE RELATIONSHIPS; LABORATORY ANIMALS; REVIEWS; DOCUMENT TYPES; IRRADIATION; PATHOGENESIS; POPULATIONS 560151* -- Radiation Effects on Animals-- Man