Ethanol induces rotational behavior in 6-hydroxydopamine lesioned mice

Journal Article · Mon Mar 09 00:00:00 EST 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90316-X· OSTI ID:6775385

Silverman, P B

Mice with unilateal striatal lesions created by 6-hydroxydopamine (6HDA) injection were screened for rotational (circling) behavior in response to injection of amphetamine and apomorphine. Those that rotated ipsilaterally in response to amphetamine and contralaterally in response to apomorphine were subsequently challenged with 1 to 3 g/kg (i.p.) ethanol. Surprisingly, ethanol induced dose related contralateral (apomorphine-like) rotation which, despite gross intoxication, was quite marked in most animals. No significant correlation was found between the number of turns made following ethanol and made after apomorphine or amphetamine. 14 references, 2 figures, 1 table.

• Research Organization: Univ. of Texas Medical School, Houston
• OSTI ID: 6775385
• Journal Information: Life Sci.; (United States), Vol. 40:10
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
BIOLOGICAL EFFECTS
MICE
BEHAVIOR
AMPHETAMINES
BRAIN
DOPAMINE
DOSE-RESPONSE RELATIONSHIPS
MORPHINE
ALCOHOLS
ALKALOIDS
AMINES
ANALEPTICS
ANALGESICS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HYDROXY COMPOUNDS
MAMMALS
NARCOTICS
NERVOUS SYSTEM
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
RODENTS
SYMPATHOMIMETICS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology