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Title: Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss

Abstract

This report presents data from 153 healthy, early postmenopausal women who were randomly allocated to two years of treatment with estrogen or placebo. Bone mineral content in the forearms was measured by single-photon absorptiometry, and bone mineral density of the lumbar spine and total-body bone mineral by dual-photon absorptiometry, before and after one and two years of treatment. At the end of the two years, there were highly significant differences of 6 to 7 percent between the estrogen and the placebo groups at all sites measured. The range of the changes of the spine measurement was twice that of the forearm and total-body measurements. It is concluded that measurement of the forearm by single-photon absorptiometry is superior to measurement of the spine by dual-photon absorptiometry both in clinical studies and in the individual patient for detecting estrogen-dependent bone loss and its treatment by estrogen replacement.

Authors:
;
Publication Date:
Research Org.:
Univ. of Copenhagen (Denmark)
OSTI Identifier:
6770520
Resource Type:
Journal Article
Journal Name:
Am. J. Med.; (United States)
Additional Journal Information:
Journal Volume: 84:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; OSTEOPOROSIS; DIAGNOSIS; SKELETON; EMISSION COMPUTED TOMOGRAPHY; COMPARATIVE EVALUATIONS; ESTRADIOL; GADOLINIUM ISOTOPES; MINERALS; PATIENTS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; WOMEN; ANIMALS; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ESTRANES; ESTROGENS; FEMALES; HORMONES; HYDROXY COMPOUNDS; ISOTOPES; MAMMALS; MAN; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RARE EARTH ISOTOPES; SKELETAL DISEASES; STEROID HORMONES; STEROIDS; TOMOGRAPHY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Riis, B J, and Christiansen, C. Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss. United States: N. p., 1988. Web. doi:10.1016/0002-9343(88)90099-X.
Riis, B J, & Christiansen, C. Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss. United States. https://doi.org/10.1016/0002-9343(88)90099-X
Riis, B J, and Christiansen, C. 1988. "Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss". United States. https://doi.org/10.1016/0002-9343(88)90099-X.
@article{osti_6770520,
title = {Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss},
author = {Riis, B J and Christiansen, C},
abstractNote = {This report presents data from 153 healthy, early postmenopausal women who were randomly allocated to two years of treatment with estrogen or placebo. Bone mineral content in the forearms was measured by single-photon absorptiometry, and bone mineral density of the lumbar spine and total-body bone mineral by dual-photon absorptiometry, before and after one and two years of treatment. At the end of the two years, there were highly significant differences of 6 to 7 percent between the estrogen and the placebo groups at all sites measured. The range of the changes of the spine measurement was twice that of the forearm and total-body measurements. It is concluded that measurement of the forearm by single-photon absorptiometry is superior to measurement of the spine by dual-photon absorptiometry both in clinical studies and in the individual patient for detecting estrogen-dependent bone loss and its treatment by estrogen replacement.},
doi = {10.1016/0002-9343(88)90099-X},
url = {https://www.osti.gov/biblio/6770520}, journal = {Am. J. Med.; (United States)},
number = ,
volume = 84:4,
place = {United States},
year = {Fri Apr 01 00:00:00 EST 1988},
month = {Fri Apr 01 00:00:00 EST 1988}
}