Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection
Journal Article
·
· Clin. Chem. (Winston-Salem, N.C.); (United States)
OSTI ID:6767526
This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a /sup 63/Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.
- Research Organization:
- Lilly Research Laboratories, Indianapolis, IN
- OSTI ID:
- 6767526
- Journal Information:
- Clin. Chem. (Winston-Salem, N.C.); (United States), Vol. 28:10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
DRUGS
QUANTITATIVE CHEMICAL ANALYSIS
ACCURACY
BLOOD CHEMISTRY
BLOOD PLASMA
ELECTRON-CAPTURE DETECTORS
GAS CHROMATOGRAPHY
INTERFERING ELEMENTS
NICKEL 63
PATIENTS
SPECIFICITY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MATERIALS
MEASURING INSTRUMENTS
NICKEL ISOTOPES
NUCLEI
RADIOISOTOPES
RADIOMETRIC GAGES
SEPARATION PROCESSES
YEARS LIVING RADIOISOTOPES
500600* - Environment
Atmospheric- Regulations- (-1989)
DRUGS
QUANTITATIVE CHEMICAL ANALYSIS
ACCURACY
BLOOD CHEMISTRY
BLOOD PLASMA
ELECTRON-CAPTURE DETECTORS
GAS CHROMATOGRAPHY
INTERFERING ELEMENTS
NICKEL 63
PATIENTS
SPECIFICITY
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMATOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
MATERIALS
MEASURING INSTRUMENTS
NICKEL ISOTOPES
NUCLEI
RADIOISOTOPES
RADIOMETRIC GAGES
SEPARATION PROCESSES
YEARS LIVING RADIOISOTOPES
500600* - Environment
Atmospheric- Regulations- (-1989)