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Title: Effect of folic acid on zinc absorption

The effect of folic acid on zinc uptake was studied in the human and in the rat. The serum zinc response to a 25 mg oral dose or zinc was measured with and without a 10 mg dose of folic acid. Serum zinc levels were measured prior to the oral dose of zinc and at hourly intervals up to 4 hours after the dose. When zinc was given along, the increases in serum zinc from baseline at hours 1, 2, 3 and 4 were 92, 118, 92 and 66 ..mu..g/dl, respectively. When both zinc and folic acid were given, the increases in serum zinc at hours 1, 2, 3 and 4 were 100, 140, 110 and 75 ..mu..g/dl, respectively. When the increases in serum zinc were plotted against time, there was no significant difference between the areas under the two curves. The everted jejunal sac from the rat was used to study the effect of folate on zinc transport using 100 ..mu..M zinc in the mucosal buffer. The addition of folic acid at levels up to 10/sup -3/M had no significant effect on zinc transport to the serosal side solution or on uptake by the intestinal mucosa. This in vivomore » study with humans and in vitro study with rat intestine does not support a direct adverse effect of folic acid on zinc absorption.« less
Authors:
; ; ;
Publication Date:
OSTI Identifier:
6754294
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA
Resource Type:
Journal Article
Resource Relation:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:4; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Research Org:
Univ. of California, Berkeley
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FOLIC ACID; BIOLOGICAL EFFECTS; ZINC; INTESTINAL ABSORPTION; METABOLISM; IN VITRO; IN VIVO; MAN; RATS; ABSORPTION; AMINO ACIDS; ANIMALS; AROMATICS; AZAARENES; CARBOXYLIC ACIDS; DRUGS; ELEMENTS; HEMATINICS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; MAMMALS; METALS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PRIMATES; PTERIDINES; RODENTS; UPTAKE; VERTEBRATES; VITAMIN B GROUP; VITAMINS 560300* -- Chemicals Metabolism & Toxicology