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Title: Marrow-tumor interactions: the role of the bone marrow in controlling chemically induced tumors

This report summarizes work done to evaluate the role of the bone marrow in tumor growth regulation. Work done with the MCA tumor showed that several subclasses of mononuclear bone marrow cells (e.g. natural regulatory cell, NRC) play a major role in the regulation of tumor growth. Experiments with the spontaneous CE mammary carcinoma system illustrate that a rapid growth of certain neoplasms may be due to the fact that through some as yet undefined mechanism the tumor eliminates mononuclear cells in the bone marrow of the host and stops their production. (KRM)
Authors:
Publication Date:
OSTI Identifier:
6746612
Report Number(s):
DOE/EV/10270-1
DOE Contract Number:
AT06-79EV10270
Resource Type:
Technical Report
Research Org:
Washington Univ., Seattle (USA). Dept. of Biological Structure
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANTIGENS; SYNERGISM; BONE MARROW CELLS; COMPARATIVE EVALUATIONS; LYMPHOCYTES; NEOPLASMS; GROWTH; IMMUNITY; IN VITRO; MAMMARY GLANDS; MICE; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; GLANDS; LEUKOCYTES; MAMMALS; MATERIALS; ORGANS; RODENTS; SOMATIC CELLS; VERTEBRATES 560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)