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Title: Lymphatic albumin clearance from psoriatic skin

Abstract

In nine patients with untreated psoriasis vulgaris, human serum albumin labelled with /sup 125/I or /sup 131/I was injected intradermally in symmetrically located involved and uninvolved skin. The activity of the depots was followed by external detection, and the arrival of labelled albumin in plasma was monitored. In involved psoriatic skin the local mean half-time (T1/2) for tracer disappearance was 20.8 +/- 8.2 (S.D.) hr and in clinically normal skin, 29.1 +/- 9.6 (S.D.) hr. The difference was significant (p less than 0.002). Accordingly, the tracer from involved skin reached higher plasma levels than the tracer from uninvolved skin. However, under slight lymphatic stasis the appearance rate of radiolabelled albumin in plasma from both tissues was minimal during 1 to 2 hours after the injection, indicating that a local direct transvascular drainage of plasma albumin from the interstitium of diseased and normal skin was negligible. We conclude that the previously demonstrated increased extravasation of plasma proteins in involved psoriatic skin is compensated by an increased lymphatic drainage of plasma proteins, and not by an increased local transvascular return.

Authors:
; ; ; ;
Publication Date:
Research Org.:
Finsen Inst., Copenhagen, Denmark
OSTI Identifier:
6743268
Resource Type:
Journal Article
Journal Name:
J. Am. Acad. Dermatol.; (United States)
Additional Journal Information:
Journal Volume: 9:6
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; PSORIASIS; PATHOLOGY; SKIN; BLOOD CIRCULATION; ALBUMINS; BLOOD-PLASMA CLEARANCE; INTRAMUSCULAR INJECTION; IODINE 125; IODINE 131; LABELLED COMPOUNDS; LYMPHATIC SYSTEM; PATIENTS; TISSUE DISTRIBUTION; TRACER TECHNIQUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CLEARANCE; DAYS LIVING RADIOISOTOPES; DISEASES; DISTRIBUTION; ELECTRON CAPTURE RADIOISOTOPES; INJECTION; INTAKE; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPES; SKIN DISEASES; 550901* - Pathology- Tracer Techniques

Citation Formats

Staberg, B, Klemp, P, Aasted, M, Worm, A M, and Lund, P. Lymphatic albumin clearance from psoriatic skin. United States: N. p., 1983. Web. doi:10.1016/S0190-9622(83)70198-2.
Staberg, B, Klemp, P, Aasted, M, Worm, A M, & Lund, P. Lymphatic albumin clearance from psoriatic skin. United States. https://doi.org/10.1016/S0190-9622(83)70198-2
Staberg, B, Klemp, P, Aasted, M, Worm, A M, and Lund, P. 1983. "Lymphatic albumin clearance from psoriatic skin". United States. https://doi.org/10.1016/S0190-9622(83)70198-2.
@article{osti_6743268,
title = {Lymphatic albumin clearance from psoriatic skin},
author = {Staberg, B and Klemp, P and Aasted, M and Worm, A M and Lund, P},
abstractNote = {In nine patients with untreated psoriasis vulgaris, human serum albumin labelled with /sup 125/I or /sup 131/I was injected intradermally in symmetrically located involved and uninvolved skin. The activity of the depots was followed by external detection, and the arrival of labelled albumin in plasma was monitored. In involved psoriatic skin the local mean half-time (T1/2) for tracer disappearance was 20.8 +/- 8.2 (S.D.) hr and in clinically normal skin, 29.1 +/- 9.6 (S.D.) hr. The difference was significant (p less than 0.002). Accordingly, the tracer from involved skin reached higher plasma levels than the tracer from uninvolved skin. However, under slight lymphatic stasis the appearance rate of radiolabelled albumin in plasma from both tissues was minimal during 1 to 2 hours after the injection, indicating that a local direct transvascular drainage of plasma albumin from the interstitium of diseased and normal skin was negligible. We conclude that the previously demonstrated increased extravasation of plasma proteins in involved psoriatic skin is compensated by an increased lymphatic drainage of plasma proteins, and not by an increased local transvascular return.},
doi = {10.1016/S0190-9622(83)70198-2},
url = {https://www.osti.gov/biblio/6743268}, journal = {J. Am. Acad. Dermatol.; (United States)},
number = ,
volume = 9:6,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 1983},
month = {Thu Dec 01 00:00:00 EST 1983}
}