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Title: Inhibition of hematopoietic recovery from radiation-induced myelosuppression by natural killer cells

We have examined the role of natural killer (NK) cells in situ in the recovery of marrow hematopoiesis in B6D2F1 mice receiving various doses of total-body irradiation (TBI) as a well-characterized model for treatment-induced myelosuppression. Applying an in situ cytotoxic approach for ablating NK 1.1 cells, we have demonstrated that NK 1.1 cells differentially inhibit the recovery of hematopoietic stem cells (CFU-S) and their progenitor cells committed to granulocyte-macrophage differentiation from a sublethal dose of TBI (9 Gy) while not affecting the recovery of progenitor cells committed to either erythroid or megakaryocyte differentiation from TBI. However, recoveries of CFU-S and progenitor cells were unaffected by the ablation of NK cells prior to a moderate dose of TBI (2 Gy). These findings provide in situ evidence that NK cells are potential inhibitors of hematopoietic recovery from treatment-induced myelosuppression.
Authors:
; ;  [1]
  1. (Wayne State Univ. School of Medicine, Detroit, MI (USA))
Publication Date:
OSTI Identifier:
6743172
Resource Type:
Journal Article
Resource Relation:
Journal Name: Radiation Research; (USA); Journal Volume: 122:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; IMMUNE SYSTEM DISEASES; RADIOINDUCTION; LYMPHOCYTES; BIOLOGICAL FUNCTIONS; STEM CELLS; BIOLOGICAL RECOVERY; BIOLOGICAL RADIATION EFFECTS; CELL DIFFERENTIATION; MACROPHAGES; MICE; WHOLE-BODY IRRADIATION; ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; EXTERNAL IRRADIATION; FUNCTIONS; IRRADIATION; LEUKOCYTES; MAMMALS; MATERIALS; PHAGOCYTES; RADIATION EFFECTS; RECOVERY; RODENTS; SOMATIC CELLS; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals