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Title: Pathogenesis of veno-occlusive liver disease after radiation

Radiation-induced liver disease is characterized structurally by progressive fibrous obliteration of central veins (veno-occlusive disease (VOD)). The pathogenesis is unknown. Samples of liver from 11 patients with radiation-induced VOD were studied by light and electron microscopy for evidence of central vein thrombosis. The patients had received fractionated radiation with total doses of 1850 to 4050 rads, or single doses of 1000 rads. In addition, six patients had received chemotherapy. We postulate that ionizing radiation injures preferentially the endothelial cells of central veins, which leads to focal deposition of fibrin. The resulting fibrin network is eventually replaced by collagen, causing fibrous occlusion.
Authors:
;
Publication Date:
OSTI Identifier:
6740948
Resource Type:
Journal Article
Resource Relation:
Journal Name: Arch. Pathol. Lab. Med.; (United States); Journal Volume: 104:11
Research Org:
Stanford Univ., CA
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FIBROSIS; RADIOINDUCTION; LIVER; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; VEINS; TRANSMISSION ELECTRON MICROSCOPY; ACUTE IRRADIATION; CHEMOTHERAPY; COLLAGEN; ENDOXAN; FIBRIN; FLUOROURACILS; FRACTIONATED IRRADIATION; PATIENTS; ACUTE EXPOSURE; ALKYLATING AGENTS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BLOOD COAGULATION FACTORS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DIGESTIVE SYSTEM; DRUGS; ELECTRON MICROSCOPY; GLANDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IRRADIATION; MEDICINE; MICROSCOPY; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; PYRIMIDINES; RADIATION EFFECTS; RADIOLOGY; SCLEROPROTEINS; THERAPY; URACILS 550603* -- Medicine-- External Radiation in Therapy-- (1980-)