Heat shock and herpes virus: enhanced reactivation without untargeted mutagenesis

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Environ. Mol. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860120206· OSTI ID:6730069

Lytle, C D; Carney, P G

Enhanced reactivation of Ultraviolet-irradiated virus has been reported to occur in heat-shocked host cells. Since enhanced virus reactivation is often accompanied by untargeted mutagenesis, we investigated whether such mutagenesis would occur for herpes simplex virus (HSV) in CV-1 monkey kidney cells subjected to heat shock. In addition to expressing enhanced reactivation, the treated cells were transiently more susceptible to infection by unirradiated HSV. No mutagenesis of unirradiated HSV was found whether infection occurred at the time of increased susceptibility to infection or during expression of enhanced viral reactivation.

• Research Organization: Center for Devices and Radiological Health, Rockville, MD (USA)
• OSTI ID: 6730069
• Journal Information: Environ. Mol. Mutagen.; (United States), Vol. 12:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HEAT
RADIOSENSITIVITY EFFECTS
MUTATIONS
RADIOINDUCTION
VIRUSES
BIOLOGICAL SHOCK
HERPES SIMPLEX
KIDNEYS
MONKEYS
MUTAGENESIS
ULTRAVIOLET RADIATION
VIABILITY
ANIMALS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY
INFECTIOUS DISEASES
MAMMALS
MICROORGANISMS
ORGANS
PARASITES
PATHOLOGICAL CHANGES
PRIMATES
RADIATIONS
SKIN DISEASES
VERTEBRATES
VIRAL DISEASES
560130* - Radiation Effects on Microorganisms