Metabolism of nephrotoxic isopropylcyclohexane in male Fischer 344 rats

Journal Article · Fri Jan 01 00:00:00 EST 1988 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398809531138· OSTI ID:6727575

Henningsen, G M; Salomon, R A; Yu, K O; Lopez, I; Roberts, J; Serve, M P

The metabolism of isopropylcyclohexane and associated renal pathology were evaluated in male Fischer 344 rats exposed by oral gavage. The rats experienced moderate proximal tubular damage similar to that produced by acyclic, branched-chain hydrocarbons. The urinary metabolites of isopropylcyclohexane included cis-4-isopropylcyclohexanol, trans-4-isopropylcyclohexanol, 2-cyclohexylpropanoic acid, 2-cyclohexyl-1,3-propanediol, 2/sup t/-hydroxy-4/sup t/-isopropylcyclohexanol, 2/sup c/-hydroxy-4/sup c/-isopropyl-cyclohexanol, and 2/sup c/-hydroxy-4/sup t/-isopropylcyclohexanol. The extent and preferred sites of oxidative metabolism of nephrotoxic hydrocarbons could potentially prove useful in elucidating the pathogenic mechanisms.

• Research Organization: Wright-Patterson AFB, OH (USA)
• OSTI ID: 6727575
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 24:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
02 PETROLEUM
CYCLOHEXANE
TOXICITY
KIDNEYS
PATHOLOGICAL CHANGES
METABOLISM
METABOLITES
ORAL ADMINISTRATION
RATS
ALKANES
ANIMALS
BODY
CYCLOALKANES
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
020600 - Petroleum- Health & Safety