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Title: Rat pro-opiomelanocortin contains sulfate

Journal Article · · Science (Washington, D.C.); (United States)

Intermediate lobes isolated from rat pituitary glands incorporated (/sup 35/S)sulfate into pro-opiomelanocortin and other adrenocorticotropic hormone-containing peptides. Incubation of intermediate lobes in medium containing the arginine analog canavanine inhibited the cleavage of pro-opiomelanocortin into smaller products. Pro-opiomelanocortin that accumulated in the presence of canavanine was also sulfated.

Research Organization:
Centre de Recherches en Endocrinologie Moleculaire, Centre Hospitalier de l'Universite, Laval, Quebec, Canada
OSTI ID:
6727456
Journal Information:
Science (Washington, D.C.); (United States), Vol. 217:4554
Country of Publication:
United States
Language:
English