Molecular size of the canine and human brain D2 dopamine receptor as determined by radiation inactivation

Journal Article · Fri Jul 01 00:00:00 EDT 1983 · Mol. Pharmacol.; (United States)

OSTI ID:6723015

Lilly, L; Fraser, C M; Jung, C Y; Seeman, P; Venter, J C

Target-size analysis (radiation inactivation) has been utilized for determination of the molecular size of the striatal D2 dopamine receptor of both canine and human membranes. The dog and human receptors were found to have a molecular size of 123,000 daltons. The identity of molecular size values is consistent with available pharmacological and biochemical evidence supporting D2 dopamine receptor identity in canine and human tissues. These data suggest that the canine receptor may be a valid model for molecular and structural investigation of the human D2 dopamine receptor.

• Research Organization: Univ. of Toronto, Ontario
• OSTI ID: 6723015
• Journal Information: Mol. Pharmacol.; (United States), Vol. 24:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DOPAMINE
RECEPTORS
INACTIVATION
RADIOINDUCTION
MOLECULAR WEIGHT
BRAIN
CELL MEMBRANES
DOGS
MAN
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM
DRUGS
HYDROXY COMPOUNDS
MAMMALS
MEMBRANES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PHENOLS
POLYPHENOLS
PRIMATES
SYMPATHOMIMETICS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560152 - Radiation Effects on Animals- Animals
551000 - Physiological Systems