Phospholipid derivatives of nucleoside analogs as prodrugs with enhanced catabolic stability

Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Cancer Res.; (United States)

OSTI ID:6721132

Matsushita, T ^[1]; Ryu, E K; Hong, C I; MacCoss, M

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1. Argonne National Lab., IL

The nucleoside 5'-diphosphate-L-1,2-dipalmitin derivatives of 1-..beta..-D-arabinofuranosylcytosine (ara-D), 9-..beta..-D-arabinofuranosyladenine (ara-A), and tubercidin have been synthesized, and their cytotoxicity has been evaluated against a mouse myeloma cell line (MPC-11) in vitro and against L1210 lymphoid leukemia both in vitro and in vivo. Sonication methods were utilized to solubilize these lipophilic derivatives in aqueous solution in order to facilitate such biological evaluation; the ara-A derivative resisted solubilization by several techniques. (JMT)

• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 6721132
• Journal Information: Cancer Res.; (United States), Vol. 41
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
EVALUATION
NUCLEOSIDES
SYNTHESIS
TUMOR CELLS
CELL KILLING
CATABOLISM
IN VITRO
IN VIVO
INHIBITION
LEUKEMIA
MICE
ONCOGENIC TRANSFORMATIONS
PHOSPHOLIPIDS
SOLUBILITY
ANIMAL CELLS
ANIMALS
DISEASES
DRUGS
ESTERS
HEMIC DISEASES
LIPIDS
MAMMALS
METABOLISM
NEOPLASMS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RIBOSIDES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)