Fat cotent of ectopic marrow implants and cellularity of resulting ossicles. [Rabbits]

Journal Article · Sat Nov 01 00:00:00 EST 1980 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-165-40976· OSTI ID:6720568

Maloney, M A; Flannery, M L; Patt, H M

The capacity of marrow stroma to transfer a microenvironment conducive to hematopoiesis was studied in rabbits by means of subcutaneous implants of autologous marrow with variable hematopoietic cellularity and fat content as determined by histologic analysis. Cellularity of marrow in ossicles present at the implantation site 3 months later was found to be sigmoidally related to cellularity of the implant. Hypocellular marrow with fat content in excess of 50% was associated with onset of a sharp increase in saturated lipids as revealed by histochemistry. These results, which confirm and extend earlier qualitative observations of a difference in potential of red and yellow marrow upon ectopic implantation, are consistent with the putative regulatory role of stromal elements in hematopoiesis.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6720568
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Vol. 165:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
TRANSPLANTS
BONE MARROW CELLS
EVALUATION
LIPIDS
BLOOD FORMATION
BONE TISSUES
RABBITS
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
MAMMALS
ORGANIC COMPOUNDS
ORGANS
SOMATIC CELLS
TISSUES
VERTEBRATES
551000* - Physiological Systems