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Title: Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein ([alpha]-catenin)

Abstract

We report the characterization of a human cDNA encompassing the complete coding region of a 945-residue putative protein (CAP-R) 80% identical to the recently described murine 102-kDa [alpha]-catenin (CAP102). The CAP-R protein mostly differs from CAP102 by the presence of a 48-residue insert. This insert exhibits similarity with a segment of the type 1 neurofibromatosis gene product. The analysis of a publicly available human [open quote]expressed sequence tag[close quotes] collection revealed the existence of another human cDNA more closely related (89% identical) to CAP 102. This strongly suggests that CAP-R is not the human homologue of the murine 102- kDa [alpha]-catenin but a new closely related gene of the vinculin family. This is further supported by the computed mutation rates falling outside the range observed for mammalian orthologous genes. Using in situ hybridization, the CAP-R gene could be mapped to the pll.l-pl2 region of human chromosome 2 and to the homologous B3-D region of mouse chromosome 6. 32 refs., 4 fig.

Authors:
 [1]; ; ; ;  [2];  [3];  [4]
  1. National Institutes of Health, Bethesda, MD (United States)
  2. Unite de Genetique Moleculaire Humaine, Paris (France)
  3. Centre d'Etude du Polymorphisme Humain, Paris (France)
  4. INSERM U242, Marseille (France)
Publication Date:
OSTI Identifier:
6717314
Resource Type:
Journal Article
Journal Name:
Genomics; (United States)
Additional Journal Information:
Journal Volume: 15:1; Journal ID: ISSN 0888-7543
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; MEMBRANE PROTEINS; GENES; ADHESION; ANCHORS; CELL MEMBRANES; CYTOPLASM; GENETIC MAPPING; HUMAN CHROMOSOME 2; HYBRIDIZATION; CELL CONSTITUENTS; CHROMOSOMES; HUMAN CHROMOSOMES; MAPPING; MEMBRANES; ORGANIC COMPOUNDS; PROTEINS; 550400* - Genetics

Citation Formats

Claverie, J M, Hardelin, J P, Legouis, R, Levilliers, J, Petit, C, Bougueleret, L, and Mattei, M G. Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein ([alpha]-catenin). United States: N. p., 1993. Web. doi:10.1006/geno.1993.1004.
Claverie, J M, Hardelin, J P, Legouis, R, Levilliers, J, Petit, C, Bougueleret, L, & Mattei, M G. Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein ([alpha]-catenin). United States. https://doi.org/10.1006/geno.1993.1004
Claverie, J M, Hardelin, J P, Legouis, R, Levilliers, J, Petit, C, Bougueleret, L, and Mattei, M G. 1993. "Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein ([alpha]-catenin)". United States. https://doi.org/10.1006/geno.1993.1004.
@article{osti_6717314,
title = {Characterization and chromosomal assignment of a human cDNA encoding a protein related to the murine 102-kDa cadherin-associated protein ([alpha]-catenin)},
author = {Claverie, J M and Hardelin, J P and Legouis, R and Levilliers, J and Petit, C and Bougueleret, L and Mattei, M G},
abstractNote = {We report the characterization of a human cDNA encompassing the complete coding region of a 945-residue putative protein (CAP-R) 80% identical to the recently described murine 102-kDa [alpha]-catenin (CAP102). The CAP-R protein mostly differs from CAP102 by the presence of a 48-residue insert. This insert exhibits similarity with a segment of the type 1 neurofibromatosis gene product. The analysis of a publicly available human [open quote]expressed sequence tag[close quotes] collection revealed the existence of another human cDNA more closely related (89% identical) to CAP 102. This strongly suggests that CAP-R is not the human homologue of the murine 102- kDa [alpha]-catenin but a new closely related gene of the vinculin family. This is further supported by the computed mutation rates falling outside the range observed for mammalian orthologous genes. Using in situ hybridization, the CAP-R gene could be mapped to the pll.l-pl2 region of human chromosome 2 and to the homologous B3-D region of mouse chromosome 6. 32 refs., 4 fig.},
doi = {10.1006/geno.1993.1004},
url = {https://www.osti.gov/biblio/6717314}, journal = {Genomics; (United States)},
issn = {0888-7543},
number = ,
volume = 15:1,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1993},
month = {Fri Jan 01 00:00:00 EST 1993}
}