Intraoperative Ir-192 implantation for early breast cancer. Techniques and results

Mansfield, C M

doi:10.1002/1097-0142(19900701)66:1<1::AID-CNCR2820660102>3.0.CO;2-X

Title: Intraoperative Ir-192 implantation for early breast cancer. Techniques and results

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Abstract

Patients with early breast cancer (T1-2 N0-1) can be treated by lumpectomy and irradiation with a local control and survival equal to more radical surgery. Between 1982 and 1988, 323 patients with early breast cancer were treated, when possible, with Ir-192 implants at the time of lumpectomy to a local dose of 2000 cGy in 40-50 hours. Ten to 14 days later, the whole breast was treated to 4500 cGy at 180 per fraction in 5 weeks. The 6-year actuarial survival for stages I and II disease was 98% and 91%, respectively, and the recurrence-free survival was 96% and 98%, respectively. When these 323 patients were evaluated by T status, a local control of 97% was the same for T1 and T2 lesions. The cosmetic results were good to excellent in 95% of the patients. This approach has improved our ability to accurately place the boost dose in the breast.

Authors:

Mansfield, C M ^[1]

Thomas Jefferson Univ. Hospital, Philadelphia, PA (USA)

Publication Date:: Sun Jul 01 00:00:00 EDT 1990

OSTI Identifier:: 6717140

Resource Type:: Journal Article

Journal Name:: Cancer (Philadelphia); (USA)

Additional Journal Information:: Journal Volume: 66:1; Journal ID: ISSN 0008-543X

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; MAMMARY GLANDS; NEOPLASMS; RADIOTHERAPY; FRACTIONATED IRRADIATION; IRIDIUM 192; MAN; PATIENTS; RADIATION DOSES; RADIATION SOURCE IMPLANTS; SURGERY; SURVIVAL CURVES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DOSES; ELECTRON CAPTURE RADIOISOTOPES; GLANDS; HEAVY NUCLEI; IMPLANTS; INTERNAL CONVERSION RADIOISOTOPES; IRIDIUM ISOTOPES; IRRADIATION; ISOMERIC TRANSITION; ISOTOPES; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANS; PRIMATES; RADIATION SOURCES; RADIOISOTOPES; RADIOLOGY; THERAPY; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 550600 - Medicine

Citation Formats


                    Mansfield, C M. Intraoperative Ir-192 implantation for early breast cancer. Techniques and results.  United States: N. p., 1990. 
        Web.  doi:10.1002/1097-0142(19900701)66:1<1::AID-CNCR2820660102>3.0.CO;2-X.

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                    Mansfield, C M. Intraoperative Ir-192 implantation for early breast cancer. Techniques and results.  United States.  https://doi.org/10.1002/1097-0142(19900701)66:1<1::AID-CNCR2820660102>3.0.CO;2-X

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                    Mansfield, C M. 1990.  
        "Intraoperative Ir-192 implantation for early breast cancer. Techniques and results".  United States.  https://doi.org/10.1002/1097-0142(19900701)66:1<1::AID-CNCR2820660102>3.0.CO;2-X.

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@article{osti_6717140,

  title        = {Intraoperative Ir-192 implantation for early breast cancer. Techniques and results},

  author       = {Mansfield, C M},

  abstractNote = {Patients with early breast cancer (T1-2 N0-1) can be treated by lumpectomy and irradiation with a local control and survival equal to more radical surgery. Between 1982 and 1988, 323 patients with early breast cancer were treated, when possible, with Ir-192 implants at the time of lumpectomy to a local dose of 2000 cGy in 40-50 hours. Ten to 14 days later, the whole breast was treated to 4500 cGy at 180 per fraction in 5 weeks. The 6-year actuarial survival for stages I and II disease was 98% and 91%, respectively, and the recurrence-free survival was 96% and 98%, respectively. When these 323 patients were evaluated by T status, a local control of 97% was the same for T1 and T2 lesions. The cosmetic results were good to excellent in 95% of the patients. This approach has improved our ability to accurately place the boost dose in the breast.},

  doi          = {10.1002/1097-0142(19900701)66:1<1::AID-CNCR2820660102>3.0.CO;2-X},

  url          = {https://www.osti.gov/biblio/6717140},
  journal      = {Cancer (Philadelphia); (USA)},

  issn         = {0008-543X},

  number       = ,

  volume       = 66:1,

  place        = {United States},

  year         = {Sun Jul 01 00:00:00 EDT 1990},

  month        = {Sun Jul 01 00:00:00 EDT 1990}

}

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