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Title: Graft irradiation in the treatment of acute rejection of renal transplants: a randomized study

A randomized study of graft irradiation in the treatment of acute rejection of renal transplants was conducted from 1978 to 1981. Patients developing clinical signs of an acute graft rejection received customary antirejection treatment in the form of intravenous administration of high-dose (1 gm per day) of methylprednisolone. They were at the same time randomized to either receive therapeutic irradiation (175 rad every other day to a total of 525 rad) or sham irradiation. Neither the patient nor the Transplant Service surgeons knew at any time whether the radiation treatment had been given. Eighty-three rejection episodes occurring in 64 grafts were entered into the study. Acute rejection was reversed in 84.5% of grafts in the control and 75% in the treated group. The incidence of recurrent rejection was higher in the treated group (66 vs. 46%) and graft survival was lower (22% vs. 54%). The study failed to demonstrate a beneficial effect of graft irradiation in the treatment of acute renal allograft rejection, when used in conjunction with high dose steriods.
Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
6716722
Resource Type:
Journal Article
Resource Relation:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States); Journal Volume: 8:5
Research Org:
Washington Univ. School of Medicine, St. Louis, MO
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GRAFTS; LOCAL IRRADIATION; IMMUNOSUPPRESSION; RADIOINDUCTION; KIDNEYS; TRANSPLANTS; RADIOTHERAPY; EVALUATION; GRAFT-HOST REACTION; IONIZING RADIATIONS; PATIENTS; STEROIDS; BODY; IRRADIATION; MEDICINE; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; RADIATIONS; RADIOLOGY; THERAPY 550603* -- Medicine-- External Radiation in Therapy-- (1980-)