Treatment of radiation- and chemotherapy-induced stomatitis

Journal Article · Sun Apr 01 00:00:00 EST 1990 · Otolaryngology and Head and Neck Surgery; (USA)

DOI:https://doi.org/10.1177/019459989010200404· OSTI ID:6714931

Carnel, S B; Blakeslee, D B; Oswald, S G; Barnes, M ^[1]

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1. Fitzsimons Army Medical Center, Aurora, CO (USA)

Severe stomatitis is a common problem encountered during either radiation therapy or chemotherapy. Most therapeutic regimens are empirical, with no scientific basis. The purpose of this study is to determine the efficacy of various topical solutions in the treatment of radiation- or chemotherapy-induced stomatitis. Eighteen patients were entered into a prospective double-blinded study to test several topical solutions: (1) viscous lidocaine with 1% cocaine; (2) dyclonine hydrochloride 1.0% (Dyclone); (3) kaolin-pectin solution, diphenhydramine plus saline (KBS); and (4) a placebo solution. Degree of pain relief, duration of relief, side effects, and palatability were evaluated. The results showed that Dyclone provided the most pain relief. Dyclone and viscous lidocaine with 1% cocaine provided the longest pain relief, which averaged 50 minutes This study provides objective data and defines useful guidelines for treatment of stomatitis.

• OSTI ID: 6714931
• Journal Information: Otolaryngology and Head and Neck Surgery; (USA), Vol. 102:4; ISSN 0194-5998
• Country of Publication: United States
• Language: English

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550600 - Medicine